{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:26:50Z","timestamp":1757586410667},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":6005,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1988,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Expression and localization of a membrane\u2010associated protein, an analog of erythrocyte protein 4.1, in the visual cortex were immunohistochemically studied in the rat, ranging in age from newborn to adult. In the adult, dendrites and somas of layer V pyramidal cells were stained by the antiprotein 4.1 antibody. In most of these immunoreactive neurons, the plasma membrane seemed to be preferentially stained. Neurons located in layers II and III of the cortex were only faintly stained, and those in layers IV and VI were not stained. At birth, the immunoreactivity was already present in pyramidal cells located in the upper part of the cortical subplate. Immature neurons located in the cortical plate were not stained by the antibody, suggesting that the 4.1\u2010like protein is expressed only in the neurons that have differentiated or are differentiating.<\/jats:p><jats:p>At postnatal days 2\u20138, immunoreactive neurons were dramatically increased in layers V and VI and intense labeling was seen at the apical dendrites of layer V pyramidal cells. Most of the stained processes of these and other neurons showed a sign of rapid dendritic growth, i.e., growth cones and filopodia. At days 10\u201317, the basal dendrites of pyramidal cells in layers II and III became detectable, although still slender. At days 20\u201337, these dendrites in layers II, III, and V became intensely immunoreactive, and dendritic spines were visualized by the antibody. Throughout all the ages, axons of neurons and neuroglia were not stained by the antibody. Also, most of the neurons in layer IV of the cortex were not immunoreactive.<\/jats:p><jats:p>These results suggest that the 4.1\u2010like protein is abundantly expressed in growing parts of the dendrites and spines. A hypothesis that this protein may play a role in synaptic plasticity in the developing visual cortex is discussed.<\/jats:p>","DOI":"10.1002\/cne.902710105","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T18:52:09Z","timestamp":1104605529000},"page":"30-43","source":"Crossref","is-referenced-by-count":9,"title":["Immunohistochemical localization of a membrane\u2010associated, 4.1\u2010like protein in the rat visual cortex during postnatal development"],"prefix":"10.1002","volume":"271","author":[{"given":"T.","family":"Tsumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Sobue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/315410a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.54.070185.001421"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/299126a0"},{"key":"e_1_2_1_5_1","first-page":"691","article-title":"The migration of neuroblasts in the developing cerebral cortex","volume":"99","author":"Berry M.","year":"1965","journal-title":"J. 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