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Radioautographic and biochemical controls after 5,7\u2010dihydroxytryptamine or 6\u2010hydroxydopamine lesioning established the respective serotonin (5\u2010HT) and catecholamine (CA) identities of the axonal varicosities labeled under the conditions of the present experiments. For descriptive purposes, the OVLT was subdivided in three parts: two parenchymal zones, one juxtaventricular, the other juxtavascular, and the vascular core. Almost 10% of all axonal varicosities in the OVLT were found to be labeled with [<jats:sup>3<\/jats:sup>H]5\u2010HT. This 5\u2010HT innervation was most prominent in the rostrocaudal and ventrodorsal portions of the juxtaventricular zone and the dorsal aspect of the juxtavascular zone; there was none in the vascular core. [<jats:sup>3<\/jats:sup>H]DA\u2010labeled varicosities were much less abundant and yet more numerous than earlier histofluorescent and immunohistochemical studies would have predicted. They predominated in the juxtavascular zone, where a majority presumably had a dopamine (DA) rather than a noradrenaline identity. Some were also found in the vascular core, where they most likely corresponded to peripheral autonomic noradrenaline endings. In the juxtaventricular zone of the OVLT, a significant proportion of the [<jats:sup>3<\/jats:sup>H]5\u2010HT\u2010labeled varicosity profiles could be observed to form axodendritic synapses, but in the juxtavascular zone no 5\u2010HT or any [<jats:sup>3<\/jats:sup>H]DA\u2010labeled ones were ever seen in synaptic junction. In the juxtavascular zone, the 5\u2010HT and the presumed DA endings established close relationships with neurosecretory axons, and with astrocytic or tanycytic processes on which they occasionally formed \u201csynaptoid contacts.\u201d A few endings of either type were also seen to abut directly on the outer basement membrane of the perivascular space. It therefore appears probable that in OVLT monoamines influence neural and nonneural elements. At a proximal level of regulation (juxtaventricular zone), 5\u2010HT could act both synaptically and nonsynaptically as an interneuronal transmitter or modulator. In contrast, distally (juxtavascular zone), both DA and 5\u2010HT could be released as neurohormones in addition to modulating neurosecretion. 5\u2010HT and DA varicosities in the OVLT could also behave as sensors for circulating factors that do not cross the blood\u2010brain barrier.<\/jats:p>","DOI":"10.1002\/cne.902720408","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T21:22:39Z","timestamp":1117228959000},"page":"545-561","source":"Crossref","is-referenced-by-count":19,"title":["Monoamine innervation of the organum vasculosum laminae terminalis (OVLT): A high resolution radioautographic study in the rat"],"prefix":"10.1002","volume":"272","author":[{"given":"Olivier","family":"Bosler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Descarries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"21","article-title":"The arterial and venous blood supply of the preoptic region in the rat","volume":"26","author":"Ambach G.","year":"1978","journal-title":"Acta Morph. 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