{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:05:23Z","timestamp":1791086723835,"version":"4.1.0"},"reference-count":85,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":5656,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1989,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The developing uncrossed retinocollicular projection in the Syrian hamster undergoes a characteristic set of changes during the first 2 postnatal weeks. The retinal fibres, which initially project across the whole superior colliculus, withdraw from the caudal part and their terminals become clustered into deep, discrete clumps rostrally. Coincident with these afferent changes, there is substantial retinal ganglion cell death. To examine whether neuronal activity plays a role in these changes, we made daily injections of the sodium channel blocker tetrodotoxin (TTX) into one or both eyes from postnatal day 2 or 4 up to day 12.<\/jats:p><jats:p>Following TTX treatment, the uncrossed terminals retracted on schedule from the caudal and superficial parts of the superior colliculus and came to lie, as normal, in the deep layers rostrally. Within the rostral superior colliculus, however, the uncrossed terminals from TTX\u2010injected eyes lost their characteristic patchy distribution and were arranged diffusely. When only one eye received TTX injections, this inhibiting effect on terminal segregation was seen only in the projections from the TTX\u2010treated eye. The effect of TTX treatment on terminal segregation was much less severe than that of unilateral enucleation, after which uncrossed terminals persist throughout the entire superior colliculus.<\/jats:p><jats:p>TTX injections appeared to have little effect on overall ganglion cell death since the total number of ganglion cells in the crossed projection from TTX\u2010treated eyes was similar to that in normal eyes. However, the relative distribution of uncrossed cells in temporal and nasal retina was altered. In eyes that received TTX injections, the proportion of uncrossed cells in nasal retina was about 1.6 times that in normal animals and was close to the proportion seen in unilaterally enucleated animals. This increase in the treated eye occurred whether one or both eyes were injected with TTX.<\/jats:p><jats:p>We conclude that neuronal activity plays a role in the segregation of uncrossed terminals into discrete clumps in rostral colliculus and in the preferential elimination of uncrossed cells from the nasal retina. The inactive uncrossed projections from TTX\u2010treated eyes showed the greatest degree of disruption. The extent of the disruption was similar whether the crossed input from the other eye was active or inactive. This suggests that the activity\u2010driven interactions between ganglion cells within one eye are more significant than those between the two eyes in shaping the final form of the uncrossed retinocollicular projection.<\/jats:p>","DOI":"10.1002\/cne.902820305","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T21:26:02Z","timestamp":1104614762000},"page":"371-388","source":"Crossref","is-referenced-by-count":59,"title":["Effects of intraocular tetrodotoxin on the development of the retinocollicular pathway in the syrian hamster"],"prefix":"10.1002","volume":"282","author":[{"given":"Lan","family":"Thompson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Holt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7100921"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237389"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(85)90171-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1523\/JNEUROSCI.04-12-02891.1984","article-title":"Activity and the formation of ocular dominance patches in dually innervated tectum of goldfish","volume":"4","author":"Boss V. C.","year":"1984","journal-title":"J. Neurosci."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/324154a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(83)90012-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236861"},{"key":"e_1_2_1_9_1","first-page":"142","article-title":"Effects of intraocular injections of tetrodotoxin on the terminal arborization of retino\u2010collicular axons in neonatal hamsters","volume":"396","author":"Cooper A. M.","year":"1987","journal-title":"J. Physiol. (Lond.)"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1984.0087"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1523\/JNEUROSCI.06-04-01021.1986","article-title":"A role for action potential activity in the development of neuronal connections in the kitten retinogeniculate pathway","volume":"6","author":"Dubin M. W.","year":"1986","journal-title":"J. Neurosci."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.17.5589"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(82)90005-0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(80)90059-X"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(79)90026-5"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902300406"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-01-00013.1984"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901940203"},{"key":"e_1_2_1_19_1","volume-title":"Organization of Behaviour","author":"Hebb D. O.","year":"1949"},{"key":"e_1_2_1_20_1","first-page":"24","article-title":"The effects of tetrodotoxin on the development of hamster retinal projections","volume":"357","author":"Holt C. E.","year":"1984","journal-title":"J. Physiol. (Lond.)"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1523\/JNEUROSCI.05-02-00255.1985","article-title":"Maturation of visual callosal connections in visually deprived kittens: A challenging critical period","volume":"5","author":"Innocenti G. M.","year":"1985","journal-title":"J. Neurosci."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/308362a0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902340309"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(84)90079-8"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/323156a0"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1975.0075"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/306465a0"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(82)90014-1"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.462177"},{"key":"e_1_2_1_30_1","first-page":"141","article-title":"Differential reduction in the number of ipsilaterally projecting ganglion cells during the development of retinofugal projections in albino and pigmented rats","volume":"7","author":"Land P. W.","year":"1981","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901910102"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(87)90021-6"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.24.9774"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/321203a0"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000124347"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90445-6"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(83)90454-8"},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1152\/jn.1983.49.2.303","article-title":"Correlated firing of cat retinal ganglion cells I. Spontaneously active inputs to X\u2010 and Y\u2010cells","volume":"49","author":"Mastronarde D. N.","year":"1983","journal-title":"J. Neurophysiol."},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1152\/jn.1983.49.2.325","article-title":"Correlated firing of cat retinal ganglion cells. II. Responses of X\u2010 and Y\u2010cells to single quantal events","volume":"49","author":"Mastronarde D. N.","year":"1983","journal-title":"J. Neurophysiol."},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238614"},{"key":"e_1_2_1_41_1","first-page":"1","volume-title":"Tracing Neural Connections With Horseradish Peroxidase","author":"Mesulam M. M.","year":"1982"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7123262"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(83)90068-8"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902350404"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(82)90125-0"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(86)90136-7"},{"key":"e_1_2_1_47_1","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1523\/JNEUROSCI.06-12-03692.1986","article-title":"Topographic targeting errors in the retinocollicular projection and their elimination by selective ganglion cell death","volume":"6","author":"O'leary D. M.","year":"1986","journal-title":"J. Neurosci."},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902190309"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/261467a0"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6828871"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/305135a0"},{"key":"e_1_2_1_52_1","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1523\/JNEUROSCI.05-05-01132.1985","article-title":"Eye\u2010specific segregation requires neural activity in three\u2010eyed Rana pipiens. J","volume":"5","author":"Reh T. A.","year":"1985","journal-title":"Neurosci."},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(82)90206-8"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(85)90087-2"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90113-7"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1967.30.5.1043"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90959-9"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90308-2"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90958-7"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902040402"},{"key":"e_1_2_1_61_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF00236636","article-title":"Increased cell number in the adult hamster retinal ganglion cell layer after early removal of one eye","volume":"52","author":"Sengelaub D. R.","year":"1983","journal-title":"Exp. Brain Res."},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.03-03-00482.1983"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-05-01378.1984"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012421"},{"key":"e_1_2_1_65_1","first-page":"589","article-title":"Tetrodotoxin infusion prevents the formation of eye\u2010specific layers during prenatal development of the cat's retinogeniculate projection","volume":"12","author":"Shatz C. J.","year":"1986","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(84)90042-7"},{"key":"e_1_2_1_67_1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1523\/JNEUROSCI.06-01-00234.1986","article-title":"Prenatal development of retinal ganglion axons: Segregation into eye\u2010specific layers within the cat's lateral geniculate nucleus","volume":"6","author":"Sretavan D. W.","year":"1986","journal-title":"J. Neurosci."},{"key":"e_1_2_1_68_1","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1523\/JNEUROSCI.06-04-00990.1986","article-title":"Prenatal development of cat retinogeniculate axon arbors in the absence of binocular interactions","volume":"6","author":"Sretavan D. W.","year":"1986","journal-title":"J. Neurosci."},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.4.997"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-08-02117.1986"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/300183a0"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/310246a0"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/290332a0"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1981.0074"},{"key":"e_1_2_1_75_1","first-page":"13","article-title":"Retinal projections of neonatal mammals visualized in wholemount preparations","volume":"358","author":"Thompson I. D.","year":"1984","journal-title":"J. Physiol. (Lond.)"},{"key":"e_1_2_1_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901680402"},{"key":"e_1_2_1_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902030403"},{"key":"e_1_2_1_78_1","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1523\/JNEUROSCI.01-12-01369.1981","article-title":"Specificity and plasticity of retinotectal connections: A computational model","volume":"1","author":"Whitelaw V. A.","year":"1981","journal-title":"J. Neurosci."},{"key":"e_1_2_1_79_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1963.26.6.1003"},{"key":"e_1_2_1_80_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1965.28.6.1029"},{"key":"e_1_2_1_81_1","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1523\/JNEUROSCI.02-05-00604.1982","article-title":"Prenatal development of retinocollicular projections in the cat: An anterograde tracer transport study","volume":"2","author":"Williams R. W.","year":"1982","journal-title":"J. Neurosci."},{"key":"e_1_2_1_82_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1523\/JNEUROSCI.03-01-00133.1983","article-title":"Loss of axons in the cat optic nerve following fetal unilateral enucleation: An electron microscopic analysis","volume":"3","author":"Williams R. W.","year":"1983","journal-title":"J. Neurosci."},{"key":"e_1_2_1_83_1","first-page":"32","article-title":"Growth cones, dying axons, and developmental fluctuations in the fibre population of the cat's optic nerve","volume":"246","author":"Williams R. W.","year":"1986","journal-title":"J. Neurosci."},{"key":"e_1_2_1_84_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1976.0087"},{"key":"e_1_2_1_85_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1979.0056"},{"key":"e_1_2_1_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(85)90082-3"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902820305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902820305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T00:49:35Z","timestamp":1697935775000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902820305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,4,15]]},"references-count":85,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,4,15]]}},"alternative-id":["10.1002\/cne.902820305"],"URL":"https:\/\/doi.org\/10.1002\/cne.902820305","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,4,15]]}}}