{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:25:35Z","timestamp":1698125135144},"reference-count":67,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":5480,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1989,10,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report on computer\u2010assisted three\u2010dimensional reconstruction of spinal cord activity associated with stimulation of the plantar cushion (PC) as revealed by [<jats:sup>14<\/jats:sup>C]\u20102\u2010deoxy\u2010D\u2010glucose (2\u2010DG) serial autoradiographs. Moderate PC stimulation in cats elicits a reflex phasic plantar flexion of the toes.<\/jats:p><jats:p>Four cats were chornically spinalized at about T6 under barbiturate anesthesia. Four to 11 days later, the cats were injected (i.v.) with 2\u2010DG (100 \u03bcCi\/kg) and the PC was electrically stimulated with needle electrodes at 2\u20135 times threshold for eliciting a reflex. Following stimulation, the spinal cord was processed for autoradiography. Subsequently, autoradiographs, representing approximately 8\u201318 mm from spinal segments L6\u2013;S1, were digitized for computer analysis and 3\u2010D reconstruction.<\/jats:p><jats:p>Several strategies of analysis were employed: (1) Three\u2010dimensional volume images were color\u2010coded to represent different levels of functional activity. (2) On the reconstructed volumes, \u201cvirtual\u201d sections were made in the horizontal, sagittal, and transverse planes to view regions of 2\u2010DG activity. (3) In addition, we were able to sample different regions within the grey and white matter semi\u2010quantitatively (i.e., pixel intensity) from section to section to reveal differences between ipsi\u2010 and contralateral activity, as well as possible variation between sections.<\/jats:p><jats:p>These analyses revealed 2\u2010DG activity associated with moderate PC stimulation, not only in the ipsilateral dorsal horn as we had previously demonstrated, but also in both the ipsilateral and contralateral ventral horns, as well as in the intermediate grey matter. The use of novel computer analysis techniques\u2014combined with an unanesthetized preparation\u2014enabled us to demonstrate that the increased metabolic activity in the lumbosacral spinal cord associated with PC stimulation was much more extensive than had heretofore been observed.<\/jats:p>","DOI":"10.1002\/cne.902880210","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T21:42:18Z","timestamp":1104615738000},"page":"326-338","source":"Crossref","is-referenced-by-count":3,"title":["Computer\u2010assisted three\u2010dimensional reconstructions of [<sup>14<\/sup>C]\u20102\u2010deoxy\u2010D\u2010glucose metabolism in cat lumbosacral spinal cord following cutaneous stimulation of the hindfoot"],"prefix":"10.1002","volume":"288","author":[{"given":"D. P.","family":"Crockett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. K.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Proshansky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Kauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. B.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Woodward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. S.","family":"Schlusselberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. D.","family":"Egger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91555-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-01-00251.1984"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(84)90054-2"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1983.49.6.1504"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-1305-8"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1523\/JNEUROSCI.06-02-00448.1986","article-title":"Functional metabolic mapping during forelimb movement in rat. I. Stimulation of motor cortex","volume":"6","author":"Collins R. C.","year":"1986","journal-title":"J. Neurosci."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90713-2"},{"issue":"1","key":"e_1_2_1_9_1","first-page":"61","article-title":"2\u2010deoxyglucose study of the plantar cushion reflex in the cat: Three\u2010dimensional reconstructions","volume":"13","author":"Crockett D. P.","year":"1987","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198206000-00005"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198410000-00012"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90938-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)91022-8"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901780403"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902350108"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.01-05-00519.1981"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1113\/jphysiol.1978.sp012337","article-title":"Sensitization and habituation of dorsal horn cells in cats","volume":"279","author":"Egger M. D.","year":"1978","journal-title":"J. Physiol. (Lond.)"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90795-2"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90669-2"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90009-0"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90686-7"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1980.sp013401"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1971.sp009536"},{"issue":"235","key":"e_1_2_1_24_1","first-page":"1","article-title":"Reflexes to foot muscles in the cat","volume":"62","author":"Engberg I.","year":"1964","journal-title":"Acta Physiol. Scand."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0149-7634(82)90024-0"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)91134-6"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90702-9"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410070414"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902290304"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-3189-6_15"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.02-08-01129.1982"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901770302"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1981.46.6.1260"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1983.50.4.961"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)91122-9"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902630405"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.17.6010"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1114332"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.11.4230"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90008-8"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(84)90189-7"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1980.tb04643.x"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902450410"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(81)90315-3"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90234-1"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91083-1"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901940303"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900960303"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901000205"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902070408"},{"key":"e_1_2_1_51_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1523\/JNEUROSCI.06-02-00463.1986","article-title":"Functional metabolic mapping during forelimb movement in rat. II. Stimulation of forelimb muscles","volume":"6","author":"Santori E. M.","year":"1986","journal-title":"J. Neurosci."},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/293574a0"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902210409"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902280403"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90377-7"},{"key":"e_1_2_1_56_1","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1152\/jn.1977.40.4.800","article-title":"Laminar analysis of 2\u2010deoxyglucose uptake in olfactory bulb and olfactory cortex of rabbit and rat","volume":"40","author":"Sharp F. R.","year":"1977","journal-title":"J. Neurophysiol."},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902240208"},{"key":"e_1_2_1_58_1","first-page":"476","article-title":"V. Relation of central nervous system glucose metabolism to neuronal structure: Sciatic nerve stimulation","volume":"14","author":"Sharp F. R.","year":"1976","journal-title":"Neurosci. Res. Progr. Bull."},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238836"},{"key":"e_1_2_1_60_1","first-page":"119","article-title":"Restriction of visual experience to a single orientation effects the organization of orientation columns in cat visual cortex","volume":"41","author":"Singer W.","year":"1981","journal-title":"Exp. Brain Res."},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90871-X"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1977.tb03919.x"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1977.tb10649.x"},{"issue":"2","key":"e_1_2_1_64_1","first-page":"1406","article-title":"Strategies for three\u2010dimensional rendering of regional brain activity from serial 14C2\u2010deoxyglucose autoradiographs","volume":"12","author":"Smith W. K.","year":"1986","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(84)90055-4"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7134981"},{"key":"e_1_2_1_67_1","volume-title":"A Stereotactic Atlas of the Brain Stem of the Cat: Comprising the Cord, the Medulla Oblongata, the Pons and the Mesencephalon","author":"Verhaart W. J. C.","year":"1964"},{"key":"e_1_2_1_68_1","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1523\/JNEUROSCI.05-07-01820.1985","article-title":"Uncrossed and crossed inhibition in the inferior colliculus of the cat: A combined 2\u2010deoxyglucose and electrophysiological study","volume":"5","author":"Webster W. R.","year":"1985","journal-title":"J. Neurosci."}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902880210","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902880210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T14:57:15Z","timestamp":1697986635000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902880210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,10,8]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,10,8]]}},"alternative-id":["10.1002\/cne.902880210"],"URL":"https:\/\/doi.org\/10.1002\/cne.902880210","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,10,8]]}}}