{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:30:25Z","timestamp":1791563425190,"version":"4.3.4"},"reference-count":74,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":5329,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1990,3,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The ventral striatum is considered to be that portion of the striatum associated with the limbic system by virtue of its afferent connections from allocortical and mesolimbic areas as well as from the amygdala. The efferent projections from this striatal region in the primate were traced by using 3H aminoacids and\n                    <jats:italic>Phaseolus vulgaris<\/jats:italic>\n                    \u2010leucoagglutinin (PHA\u2010L). Particular attention was paid to the topographic organization of terminal fields in the globus pallidus and substantia nigra, the projections to non\u2010extrapyramidal areas, the relationship between projections from the nucleus accumbens and the other parts of the ventral striatum, and the comparison between ventral and dorsal striatal projections.\n                  <\/jats:p>\n                  <jats:p>This study demonstrates that in monkeys a circumscribed region of the globus pallidus receives topographically organized efferent fibers from the ventral striatum. The ventral striatal fibers terminate in the ventral pallidum, the subcommissural part of the globus pallidus, the rostral pole of the external segment, and the rostromedial portion of the internal segment. The more central and caudal portions of the globus pallidus do not receive this input. This striatal output appears to remain segregated from the dorsal striatal efferent projections to pallidal structures.<\/jats:p>\n                  <jats:p>Fibers from the ventral striatum projecting to the substantia nigra are not as confined to a specific region as those projecting to the globus pallidus. Although the densest terminal fields occur in the medial portion, numerous fibers also extend laterally to innervate the dorsal stratum of dopaminergic neurons of the substantia nigra and the retrorubral area. Furthermore, they project throughout the rostral\u2010caudal extent of the substantia nigra. Projections from the medial part of the ventral striatum reach the more caudally located pedunculopontine tegmental nucleus. Thus unlike the above described terminals in the globus pallidus, the ventral striatum project widely throughout the substantia nigra, a fact that indicates that they may contribute to the integration between limbic and other output systems of the striatum.<\/jats:p>\n                  <jats:p>Finally, the ventral striatum projects to non\u2010extrapyramidal regions including the bed nucleus of the stria terminals, the nucleus basalis magnocellularis, the lateral hypothalamus, and the medial thalamus.<\/jats:p>","DOI":"10.1002\/cne.902930210","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:53:39Z","timestamp":1104598419000},"page":"282-298","source":"Crossref","is-referenced-by-count":257,"title":["Topographic organization of the ventral striatal efferent projections in the rhesus monkey: An anterograde tracing study"],"prefix":"10.1002","volume":"293","author":[{"given":"S. N.","family":"Haber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Lynd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. J.","family":"Groenewegen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.002041"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(88)90217-5"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902670404"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90257-4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90382-9"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901840104"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)91001-1"},{"key":"e_1_2_1_9_1","first-page":"1","volume-title":"The Basal Ganglia","author":"Carpenter M. B.","year":"1976"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)91113-6"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90443-4"},{"key":"e_1_2_1_12_1","first-page":"1","volume-title":"The Neurobiology of the Nucleus Accumbens","author":"Chronister R. B.","year":"1981"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90060-3"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237932"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(84)90127-7"},{"key":"e_1_2_1_16_1","first-page":"75","article-title":"The primate globus pallidus. A Golgi and electron microscope study","volume":"15","author":"Fox C. H.","year":"1974","journal-title":"J. F. Hirnforschung"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(86)90009-3"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902360404"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90940-5"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901710305"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902420406"},{"key":"e_1_2_1_22_1","first-page":"447","volume-title":"Cerebral Cortex","author":"Goldman\u2010Rakic P. S.","year":"1986"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(81)90131-7"},{"key":"e_1_2_1_24_1","unstructured":"Groenewegen H. J. andH. W.Berendse(1989)Connections of the subthalamic nucleus and limbic\u2010related parts of the basal ganglia. An anatomical tracing study (submitted)."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902230303"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(80)90038-X"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(82)90055-0"},{"key":"e_1_2_1_28_1","first-page":"45","volume-title":"Neural Mechanisms of Disorders of Movement","author":"Groenewegen H. J.","year":"1989"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91623-9"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.5.1408"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/0306-4522(81)90188-3","article-title":"Correlation between met\u2010enkephalin and substance P immunoreactivity in the primate globus pallidus","volume":"6","author":"Aber S.","year":"1981","journal-title":"Neuroscience"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/0306-4522(82)91118-6","article-title":"The distribution of enkephalin immunoreactive fibers and terminals in the monkey central nervous system: An immunohistochemical study","volume":"7","author":"Aber S. N.","year":"1982","journal-title":"Neuroscience"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","unstructured":"Aber S. N. andH.Groenewegen(1989) The interrelationship of the distribution of neuropeptides and tyrosine hydroxylase immunoreactivity in the human substantia nigra.J. Comp. Neurol. (submitted).","DOI":"10.1002\/cne.902900105"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0306-4522(83)90291-9","article-title":"Ramifications of the globus pallidus in the rat as indicated by patterns of immunohistochemistry","volume":"9","author":"Aber S. N.","year":"1983","journal-title":"Neuroscience"},{"issue":"1","key":"e_1_2_1_35_1","first-page":"33","article-title":"The comparison between enkephalinlike and dynorphin\u2010like immunoreactivity in both monkey and human globus pallidus and substantia nigra","volume":"33","author":"Aber S. N.","year":"1983","journal-title":"Life Sci."},{"key":"e_1_2_1_36_1","first-page":"1011","article-title":"The comparative distribution of enkephalin, dynorphin and substance P in the human globus pallidus and basal forebrain","volume":"4","author":"Laber S. N.","year":"1985","journal-title":"Neuroscience"},{"key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/cne.902350304","article-title":"Efferent connections of the ventral pallidum. Evidence of a dual striatopallidofugal pathway","volume":"235","author":"Laber S. N.","year":"1985","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00238343","article-title":"Projections of precentral and premotor cortex to the red nucleus and other midbrain areas in Macaca fiscicularis","volume":"34","author":"Lartmann\u2010von Monakow K.","year":"1979","journal-title":"Exp. Brain Res."},{"key":"e_1_2_1_39_1","first-page":"95","volume-title":"Limbic Mechanisms","author":"Leimer L.","year":"1978"},{"key":"e_1_2_1_40_1","first-page":"177","volume-title":"Golgi Centennial Symposium: Perspectives in Neurobiology","author":"Heimer L.","year":"1975"},{"key":"e_1_2_1_41_1","first-page":"75","volume-title":"The Neurobiology of the Nucleus Accumbens","author":"Hemphill M.","year":"1981"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901730107"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902770304"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902360304"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(71)90129-4"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(82)90198-1"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(82)90067-7"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(67)90004-2"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01187858"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-0716-8_6"},{"key":"e_1_2_1_51_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-08-024408-2.50006-3","volume-title":"Dopaminergic Ergot Derivates and Motor Function","author":"Nauta W. J. H.","year":"1979"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(66)90103-X"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(78)90041-6"},{"key":"e_1_2_1_54_1","volume-title":"Cytoarchitecture of the Human Brain Stem","author":"Olszewski J.","year":"1954"},{"key":"e_1_2_1_55_1","volume-title":"Comparative Neurobiology of the Basal Ganglia","author":"Parent A.","year":"1986"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90802-2"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)91224-1"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902270207"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(83)90173-9"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901750107"},{"key":"e_1_2_1_61_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0304-3940(84)90379-3","article-title":"Amygdalostriatal projections in the rat. Topographical organization and fiber morphology shown using the lectin PHA\u2010L as an anterograde tracer","volume":"47","author":"Russchen F. T.","year":"1985","journal-title":"Neurosci. Lett."},{"key":"e_1_2_1_62_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.902420102","article-title":"The afferent connections of the substantia innominata in the monkey, Macaca fascicularis.","volume":"242","author":"Russchen F. T.","year":"1987","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902560202"},{"key":"e_1_2_1_64_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0006-8993(85)90530-X","article-title":"Amygdalostriatal projections in the monkey (Macaca fascicularis). An anterograde tracing study","volume":"329","author":"Russchen F. T.","year":"1984","journal-title":"Brain Res."},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90530-X"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902690302"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902590403"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-03-00776.1985"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(86)90159-4"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(62)90067-5"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(67)90166-5"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(70)90196-2"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901990205"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90271-2"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90059-8"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902930210","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902930210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T06:36:18Z","timestamp":1697956578000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902930210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3,8]]},"references-count":74,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,3,8]]}},"alternative-id":["10.1002\/cne.902930210"],"URL":"https:\/\/doi.org\/10.1002\/cne.902930210","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,3,8]]}}}