{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T22:18:28Z","timestamp":1776291508363,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":5284,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1990,4,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mandibular closer muscles of the locust receive innervation that is immunoreactive for the putative transmitter 5\u2010hydroxytrptamine (5\u2010HT). Cobalt\u2010labelling suggests that the origin of this innervation is a group of cells located anteriorly in the suboesophageal ganglion. Bath application of 5\u2010HT while the muscles are active produces marked changes in the contractions, increasing their amplitude, rate of contraction, and rate of relaxation. Incubation of isolated muscles with 5\u2010HT shows that this amine elevates the levels of the cyclic nucleotide cyclic adenosine monophosphate (cAMP). In addition compounds that artificially elevate the levels of cAMP in the muscle\u20103\u2010isobutyl\u20101\u2010methylxanthine (IBMX), forskolin, and the cAMP analogue 8\u2010(4\u2010chlorophenylthio) cAMP\u2010mimic the actions of 5\u2010HT, whereas a potent inhibitor of insect adenylate cyclase, adenosine, considerably delays the onset of the effects produced by 5\u2010HT.<\/jats:p><jats:p>The effects observed with 5\u2010HT in the mandibular muscle are similar to those of octopamine in the locust extensor tibiae muscle, and it is possible that this is an analogous modulatory system.<\/jats:p>","DOI":"10.1002\/cne.902940409","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T21:59:15Z","timestamp":1104616755000},"page":"623-632","source":"Crossref","is-referenced-by-count":36,"title":["Serotoninergic innervation of the locust mandiblar closer muscle modulates contractions through the elevation of cyclic adenosine monophosphate"],"prefix":"10.1002","volume":"294","author":[{"given":"Richard A.","family":"Baines","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Mark","family":"Tyrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger G. H.","family":"Downer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90753-3"},{"key":"e_1_2_1_3_1","unstructured":"Baines R. A.(1988)Role of 5\u2010hydroxytryptamine and peptides in the innervation of locust salivary glands and mandibular muscles. Ph. D. thesis University of Manchester Institute of Science and Technology. England."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00619359"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00619358"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00613442"},{"key":"e_1_2_1_7_1","unstructured":"Br\u00e5unig P.(1987b)Neurosecretory cells of the locust suboesophageal ganglion. Satellite symposium (abstracts). II World Congress of Neuroscience Tihany Hungary."},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1242\/jeb.85.1.349","article-title":"Use of an operational amplifier signal differentiator reveals that octopamine increases the rate of development of neurally evoked tension in insect muscle","volume":"85","author":"Buchan P. B.","year":"1980","journal-title":"J. Exp. Biol."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0898-6568(89)90023-5"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1974.sp010445"},{"key":"e_1_2_1_11_1","first-page":"81","article-title":"Forskolin, adenylate cyclase and cell physiology: An overview","volume":"17","author":"Daly J. W.","year":"1984","journal-title":"Adv. Cyclic Nucleotide Protein Phosphor. Res."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902590409"},{"key":"e_1_2_1_13_1","volume-title":"Cockroaches as Model Systems for Neurobiology: Applications in Biomedical Research","author":"Downer R. G. H.","year":"1989"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.12.3371"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013853"},{"key":"e_1_2_1_16_1","first-page":"48","article-title":"Properties of modulatory octopamine receptors in the locust","volume":"88","author":"Evans P. D.","year":"1982","journal-title":"Ciba. Fdn. Symp."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015112"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015113"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-030812-8.50017-4"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1113\/jphysiol.1985.sp015801","article-title":"Regional differences in responsiveness to octopamine within a locust skeletal muscle","volume":"336","author":"Evans P. D.","year":"1985","journal-title":"J. Physiol. Lond."},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1242\/jeb.124.1.143","article-title":"Peptidergic and aminergic modulation of insect skeletal muscle","volume":"124","author":"Evans P. D.","year":"1986","journal-title":"J. Exp. Biol."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/270257a0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014102"},{"key":"e_1_2_1_24_1","first-page":"29P","article-title":"Release and uptake of 5\u2010hydroxytryptamine (5\u2010HT) by a single 5\u2010HT containing neurone","volume":"260","author":"Gerschenfeld H. M.","year":"1976","journal-title":"J. Physiol. Lond."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480110109"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(86)90240-X"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1242\/jeb.89.1.159","article-title":"Amines and a peptide as neurohormones in lobsters: action on neuromuscular preparations and preliminary behavioural studies","volume":"89","author":"Kravitz E. A.","year":"1980","journal-title":"J. Exp. Biol."},{"key":"e_1_2_1_28_1","first-page":"297","article-title":"Functional studies on the metacerebral cells of Aplysia. Abstr","volume":"4","author":"Kupferman I.","year":"1974","journal-title":"Soc. Neurosci."},{"key":"e_1_2_1_29_1","unstructured":"Lutz E. M.(1985)Identification of sensory transmitters in the locust. Ph. D. thesis University of Manchester Institute of Science and Technology England."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00610463"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00610464"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-4035(70)90015-7"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0305-0491(80)90035-8","article-title":"Adenylate cyclase in silkworm","volume":"65","author":"Morishima I.","year":"1980","journal-title":"Inhibition by adenosine. Comp. Biochem. Physiol."},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00307447"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90088-1"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902270303"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1973.tb00067.x"},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/jn.1979.42.3.791","article-title":"I. Modulation of muscle contractility by the serotonergic metacerebral cells in Aplysia: Evidence for a role of cyclic adenosine monophosphate","volume":"42","author":"Weiss K. R.","year":"1979","journal-title":"J. Neurophysiol."},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1242\/jeb.134.1.247","article-title":"Octopaminergic modulation of flight muscle in the locust","volume":"134","author":"Whim M. D.","year":"1988","journal-title":"J. Exp. Biol."}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902940409","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902940409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T09:28:35Z","timestamp":1697966915000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902940409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4,22]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,4,22]]}},"alternative-id":["10.1002\/cne.902940409"],"URL":"https:\/\/doi.org\/10.1002\/cne.902940409","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,4,22]]}}}