{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T07:15:59Z","timestamp":1698131759124},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":5261,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1990,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Various circumstances have brought about a dispute concerning the immunologically privileged status of the central nervous system (CNS). Using a transplantation paradigm, we have examined the cellular events associated with an experimentally induced focal assault on the CNS by the immune system. Chunks of embryonic mouse cortex were transplanted into neonatal rat brains and allowed to survive for 4 weeks. The adult rats then received a skin graft of donor origin to induce rejection of the transplanted tissue. Animals were sacrificed at various time points and examined histologically and immunocytochemically. Under these circumstances, the transplant is rejected via a first\u2010set rejection response, and astrocytes of donor origin appear to be the primary target of the host immune system. Expression of class I and class II major histocompatibility antigens is noted to correlate with lymphocytic invasion of the transplant.<\/jats:p>","DOI":"10.1002\/cne.902950307","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T21:59:57Z","timestamp":1104616797000},"page":"428-437","source":"Crossref","is-referenced-by-count":18,"title":["Cellular events associated with peripherally induced rejection of mature neural xenografts placed into neonatal rat brains"],"prefix":"10.1002","volume":"295","author":[{"given":"M. G.","family":"Backes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond D.","family":"Lund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. F.","family":"Lagenaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. W.","family":"Kunz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"T. J.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.62.2.0169"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60930-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901530104"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(86)80006-6"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237035"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902770305"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.102.1.49"},{"key":"e_1_2_1_9_1","first-page":"126","article-title":"Biology of disease. Genetic aspects of cellular interactions in the immune response","volume":"55","author":"Cramer D. V.","year":"1986","journal-title":"Lab. Invest."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)91112-6"},{"key":"e_1_2_1_11_1","first-page":"278","article-title":"Cerebral cicatrix; reaction of neuroglia and microglia to brain wounds","volume":"41","author":"del Rio\u2010Hortega P.","year":"1927","journal-title":"Bull. Johns Hopkins Hosp."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(85)80036-9"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.4049\/jimmunol.134.6.3785","article-title":"Astrocytes as antigen presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation","volume":"134","author":"Fierz W.","year":"1985","journal-title":"J. Immunol."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.129.6.2413"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(86)90094-9"},{"key":"e_1_2_1_16_1","first-page":"1205","article-title":"Functional brain tissue transplantation: Reversal of lesion\u2010induced rotation by intraventricular substantia nigra and adrenal medulla grafts, with a note on intracranial retinal grafts","volume":"18","author":"Freed W. J.","year":"1983","journal-title":"Biol. Psychiatry"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90123-0"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902630310"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1985.0039"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(86)90543-4"},{"key":"e_1_2_1_21_1","first-page":"1501","article-title":"Cellular and genetic control of antibody response in vitro. IV. Expression of Ia antigens on accessory cells is required for responses to soluble antigens including a response under Ir gene control","volume":"121","author":"Hodes R.","year":"1978","journal-title":"J. Immunol."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/30.10.6182185"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000112249"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901940307"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(85)90004-9"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(88)90082-9"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902490108"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsscb.1981.380150404"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.20.6476"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(85)90428-8"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198808000-00006"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198704023161402"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)91499-4"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/31.12.6355290"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-197811000-00018"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90725-7"},{"key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0079-6123(08)60294-0","article-title":"Immunological implications of xenogeneic or allogeneic transplantation to neonatal rats","volume":"78","author":"Rao K.","year":"1988","journal-title":"Prog. Brain Res."},{"key":"e_1_2_1_38_1","first-page":"247","article-title":"The role of astrocytes in immune responses within the central nervous system","volume":"31","author":"Salamat S. M.","year":"1988","journal-title":"Neurol. and Neurobiol."},{"key":"e_1_2_1_39_1","first-page":"88","volume-title":"Immunobiology of Transplantation, Cancer and Pregnancy","author":"Santiago\u2010Delpin E. A.","year":"1983"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1966.00470130066006"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(87)90185-4"},{"key":"e_1_2_1_42_1","first-page":"14","article-title":"Transplantation of rat sarcoma in adult heterogeneous animals","volume":"1","author":"Shirai Y.","year":"1921","journal-title":"Jap. Med. World."},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(86)90002-0"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(87)90121-4"},{"key":"e_1_2_1_45_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1242\/jeb.22.3-4.221","article-title":"Development of rat eye in graft","volume":"22","author":"Tansley K.","year":"1946","journal-title":"J. Exp. Biol."},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/69.2.103"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198004000-00002"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/310688a0"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902830109"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902950307","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902950307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T21:00:40Z","timestamp":1698008440000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902950307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,5,15]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,5,15]]}},"alternative-id":["10.1002\/cne.902950307"],"URL":"https:\/\/doi.org\/10.1002\/cne.902950307","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,5,15]]}}}