{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:12:20Z","timestamp":1761822740190},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":5207,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1990,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The origins and overall distribution of perivascular nerve fibers showing calcitonin gene\u2010related peptide\u2010like immunoreactivity (CGRP\u2010LI) in the major cerebral arteries were investigated immunohistochemically in the dog by using whole\u2010mount preparations of the arterial trees around the circle of Willis. Perivascular nerve fibers with CGRP\u2010LI were seen most abundantly in the basilar artery, vertebral artery, common anterior cerebral artery, proximal part of the anterior cerebral artery, and terminal part of the internal carotid artery. They were far less numerous in the middle cerebral artery, posterior cerebral artery, superior cerebellar artery, and distal part of the anterior cerebral artery. Neuronal cell bodies with CGRP\u2010LI were observed in the trigeminal, nodose, superior cervical, and dorsal root ganglia.<\/jats:p><jats:p>CGRP\u2010LI fibers in the large pial arteries in the circle of Willis were eliminated ipsilaterally after unilateral transection of the ophthalmic division of the trigeminal nerve, and slightly reduced in number ipsilaterally after unilateral transection of the maxillary division of the trigeminal nerve. They did not show any noticeable changes after unilateral transection of the mandibular division of the trigeminal nerve. On the other hand, CGRP\u2010LI fibers in the basilar and vertebral arteries did not show any appreciable changes after unilateral transection of the trigeminal nerve, but they were eliminated after bilateral ganglionectomy of the dorsal root ganglia of the first, second, and third cervical nerves. After ganglionectomy of the ciliary, pterygopalatine, otic, nodose, or superior cervical ganglion, no changes were observed in perivascular nerve fibers with CGRP\u2010LI in the major cerebral arteries.<\/jats:p><jats:p>The data indicate that perivascular nerve fibers with CGRP\u2010LI in the large pial arteries forming the circle of Willis originate mainly from the ophthalmic division of the trigeminal nerve, and partly from the maxillary division of the trigeminal nerve, and that CGRP\u2010LI fibers in the basilar artery and distal part of the vertebral artery originate mainly from the dorsal root ganglia of the upper cervical nerves.<\/jats:p>","DOI":"10.1002\/cne.902970205","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T22:04:46Z","timestamp":1104617086000},"page":"219-226","source":"Crossref","is-referenced-by-count":26,"title":["Origins and distribution of cerebrovascular nerve fibers showing calcitonin gene\u2010related peptide\u2010like immunoreactivity in the major cerebral artery of the dog"],"prefix":"10.1002","volume":"297","author":[{"given":"Kazuhiko","family":"Nozaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(86)90293-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(86)90284-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(84)90239-0"},{"key":"e_1_2_1_5_1","first-page":"126","article-title":"Functional role of perivascular peptides in the control of cerebral circulation","volume":"8","author":"Edvinsson L.","year":"1985","journal-title":"T. 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