{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T19:05:32Z","timestamp":1698347132668},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":5152,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cell migration and axon growth during neural development rely upon cell\u2010cell and cell\u2010matrix interactions mediated by surface glycoproteins. The surface glycoprotein recognized on leech neurons by monoclonal antibody Lan3\u20102 has previously been implicated in the process of axon fasciculation during regeneration in adults. In adult leeches, Lan3\u20102 binds to a carbohydrate epitope of a 130 kD protein. The present study demonstrates that in embryos the antibody binds to the same carbohydrate epitope of glycoproteins with molecular weights of 130 kD and higher. As a first step in evaluating a possible role of the Lan3\u20102 glycoprotein or the cells that express it during neural development, we determined its distribution in the developing nervous system of the leech <jats:italic>Hirudo medicinalis.<\/jats:italic> In embryos, Lan3\u20102 epitope is expressed on fasciculated sensory afferents and it appears on the cell bodies before neurite outgrowth. The sensory fibers appear rostrally by embryonic day 10, less than halfway through development. Earlier, by 7 days of development at 20\u00b0C, Lan3\u20102 binds to previously undocumented cell types: (1) cells appearing along the embryonic midline and (2) a cluster of cells located at the rostral edge of the germinal plate. These cells only transiently express this antigen and are present at critical left\u2010right and rostrocaudal boundaries during a period of cell proliferation, movement, and migration that produces the nervous system. Thus the Lan3\u20102 surface glycoprotein or the cells expressing it are candidates for involvement in axon fasciculation, cell migration, and directed axonal growth.<\/jats:p>","DOI":"10.1002\/cne.902990109","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T22:07:36Z","timestamp":1104617256000},"page":"123-131","source":"Crossref","is-referenced-by-count":13,"title":["Expression of surface glycoproteins early in leech neural development"],"prefix":"10.1002","volume":"299","author":[{"given":"Ellen","family":"McGlade\u2010McCulloh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth J.","family":"Muller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Zipser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90072-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/260054a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/304062a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(82)90203-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.223.4635.493"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(82)90327-X"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0166-2236(85)90103-1","article-title":"Axon guidance in the wing of Drosophila","volume":"8","author":"Blair S. 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