{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:46:14Z","timestamp":1761518774420},"reference-count":74,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":5145,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1990,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The distribution of the neuropeptides methionine\u2010 and leucine\u2010enkephalins, substance P, FMRFamide, neuropeptide Y, and vasoactive intestinal peptide, as well as the biogenic amine serotonin was studied in the optic tectum of the Atlantic salmon by means of immunocytochemistry. Peroxidase\u2010antiperoxidase and indirect immunofluorescence methods were used to compare the differential laminar distribution of each of these substances. Nine parts of the optic tectum were selected for analysis on frontal sections: median, dorsolateral, and ventrolateral areas at rostral, medial, and caudal levels.<\/jats:p><jats:p>Methionine\u2010 and leucine\u2010enkephalin immunoreactive fibers were found in discrete sublayers in the following strata: stratum opticum, stratum fibrosum et griseum superficiale, stratum griseum centrale, stratum, and album centrale. Most of the substance P\u2010, serotonin\u2010, and vasoactive intestinal peptide\u2010immunoreactive fibers were found in the stratum album centrale, whereas the FMRFamide\u2010 and neuropeptide Y\u2010immunoreactive fibers were more or less randomly distributed within most of the strata of the optic tectum. Neuropeptide Y\u2010immunoreactive cell bodies were located in the stratum periventriculare.<\/jats:p><jats:p>We suggest an extrinsic origin for most of the immunoreactive fibers observed in the optic tectum, except for the neuropeptide Y\u2010immunoreactive fibers that probably originate in the periventricular neurons. Although retinal peptidergic input to the optic tectum has been proposed in other vertebrates, there is no evidence that any of the neuropeptidelike or serotonin immunoreactive fibers in the optic tectum of the salmon should be of retinal origin. Differences and similarities with the distribution of neuropeptides in the optic tectum in representatives of other vertebrate classes are discussed.<\/jats:p>","DOI":"10.1002\/cne.902990207","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T22:08:33Z","timestamp":1104617313000},"page":"229-241","source":"Crossref","is-referenced-by-count":36,"title":["Distribution of met\u2010enkephalin, leu\u2010enkephalin, substance P, neuropeptide Y, FMRFamide, and serotonin immunoreactivities in the optic tectum of the Atlantic salmon (<i>Salmo salar<\/i> L.)"],"prefix":"10.1002","volume":"299","author":[{"given":"Elena","family":"Vecino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01170826"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902750108"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902190306"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/327155a0","article-title":"Substance\u2010P\u2010immunoreactive retinal ganglion cells and their central axon terminal in the rabbit","volume":"357","author":"Brecha N.","year":"1987","journal-title":"Nature"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00493378"},{"key":"e_1_2_1_7_1","first-page":"123","article-title":"Neuropeptide Y (NPY)\u2010like immunoreactive neurons in the brain and pituitary of the amphibian Rana catesbeiana","volume":"4","author":"Cailliez D.","year":"1987","journal-title":"Zool. Sci."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90240-9"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(88)90217-0"},{"key":"e_1_2_1_10_1","volume-title":"Histologie du Systeme Nerveux","author":"Cajal S. R.","year":"1911"},{"key":"e_1_2_1_11_1","first-page":"93","volume-title":"Cytochemical Methods in Neuroanatomy","author":"Chan\u2010Palay V.","year":"1982"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01990201"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)91011-9"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/BF00492630","article-title":"Histochemical localization of acetylcholinesterase in the cerebellum and optic tectum of four freshwater teleosts","volume":"45","author":"Contestabile A.","year":"1975","journal-title":"Histochem."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901780108"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(85)90455-3"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902680409"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901650204"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00213845"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902660208"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/cne.902560403","article-title":"Distribution of choline acetyltransferase immunoreactive neurons in the brain of a cyprinid teleost (Phoxinus phoxinus, L)","volume":"256","author":"Ekstr\u00f6rn P.","year":"1987","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_22_1","first-page":"201","article-title":"Distribution of serotonin\u2010immunoreactive neurons in the brain of sockeye salmon fry","volume":"2","author":"Ekstr\u00f6m P.","year":"1989","journal-title":"J. Chem. Neuroanat."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902260302"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902540304"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90430-1"},{"key":"e_1_2_1_26_1","first-page":"203","article-title":"Monoamines and neuropeptides in the isthmal brain stem\/locus coeruleus area of teleost fishes","volume":"2","author":"Ekstr\u00f6m P.","year":"1989","journal-title":"Eur. J. Neuroscience (Suppl.)"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF00303149","article-title":"Distribution of serotonin\u2010immunoreactivity in the diencephalon and mesencephalon of the trout, Salmo gairdneri. Cell bodies, fibers and terminals, Anat","volume":"169","author":"Frankenhuis\u2010van den Heuvel T. H. M.","year":"1984","journal-title":"Embryol."},{"key":"e_1_2_1_28_1","first-page":"675","article-title":"Dendritic localization and density of acetylcholine receptors in single cells in slices of goldfish optic tectum","volume":"5","author":"Freeman J. A.","year":"1979","journal-title":"Neurosci. Abstr."},{"key":"e_1_2_1_29_1","first-page":"241","article-title":"Serotonin neurons in nucleus raphe dorsalis and paragigantocellularis of the cat contain enkephalin","volume":"77","author":"Glazer E. J.","year":"1981","journal-title":"J. Physiol. (Paris)"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90147-7"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(88)90116-4"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901810303"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901910409"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00213771"},{"key":"e_1_2_1_35_1","first-page":"189","volume-title":"Cytochemical Methods in Neuroanatomy","author":"Karten H. J.","year":"1982"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902120208"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902170302"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.15.5736"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800001024"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902260206"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901540106"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(78)90116-1"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(83)90008-5"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902810205"},{"key":"e_1_2_1_45_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0006-8993(87)90900-0","article-title":"Immunocytochemical analysis of proenkephalin\u2010derived peptides in the amphibian hypothalamus and optic tectum","volume":"416","author":"Merchenthaler I.","year":"1987","journal-title":"Brain Res."},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)91323-2"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902850111"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901820307"},{"key":"e_1_2_1_49_1","first-page":"413","article-title":"The visual system of the trout Salmo irideus Gibb: A degeneration and radioautographic study","volume":"20","author":"Pinganaud G.","year":"1979","journal-title":"J. Hirnforsch."},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90010-1"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00218788"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902590106"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902080104"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902260105"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901910303"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902790109"},{"key":"e_1_2_1_57_1","first-page":"68","volume-title":"Handbook of Chemical Neuroanatomy, Vol. 3: Classical Transmitters and Transmitter Receptors in the CNS","author":"Steinbusch H. W. M.","year":"1984"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.3.940"},{"key":"e_1_2_1_59_1","first-page":"47","article-title":"Unusual properties of Atlantic cod (Gadus morhua) brain microtubules","volume":"2","author":"Stromberg E.","year":"1989","journal-title":"Bioscience Abstr."},{"key":"e_1_2_1_60_1","first-page":"680","article-title":"Peptide immunoreactive neurons in the human retina","volume":"29","author":"Tornqvist K.","year":"1988","journal-title":"Invest. Ophthalm. Visual. Sci."},{"key":"e_1_2_1_61_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF00492773","article-title":"A critical examination of the occurrence of FMRFamide immunoreactivity in the brain of guinea pig and rat","volume":"80","author":"Triepel J.","year":"1984","journal-title":"Histochem."},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901510404"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(83)90036-X"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901540104"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001750218"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90254-4"},{"key":"e_1_2_1_67_1","unstructured":"Vecino E.(1989)Distribuci\u00f3n de neuropeptidos en el Sistema Nervioso Central de Salmo gairdneri y de Salmo salar: Estudio inmunocitoqu\u00edmico. Ph. D. dissertation University of Salamanca Spain."},{"key":"e_1_2_1_68_1","first-page":"191","article-title":"Immunocytochemical study of substance P\u2010like cell bodies and fibers in the brain of the rainbow trout, Salmo gairdneri","volume":"165","author":"Vecino E.","year":"1989","journal-title":"J. Anat."},{"key":"e_1_2_1_69_1","first-page":"4","article-title":"Distribution of Neuropeptide Y\u2010like immunoreactive cell bodies in the brain of the rainbow trout Salmo gairdneri","volume":"63","author":"Vecino E.","year":"1989","journal-title":"ENA Abstract."},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(81)90194-9"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)91248-0"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91162-5"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90728-X"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1159\/000118643"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902730309"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902990207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902990207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T13:47:00Z","timestamp":1697982420000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902990207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9,8]]},"references-count":74,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,9,8]]}},"alternative-id":["10.1002\/cne.902990207"],"URL":"https:\/\/doi.org\/10.1002\/cne.902990207","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,9,8]]}}}