{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:47:28Z","timestamp":1790927248169,"version":"4.1.0"},"reference-count":80,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":4858,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1991,6,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Blood\u2010nerve barrier tissues (endoneurial blood vessels and perineurium) of the frog's sciatic nerve were studied during chronic Wallerian degeneration to determine whether barrier function depends on the presence of intact axons. Sciatic nerves of adult frogs were transected in the abdominal cavity; the ends were tied to prevent regeneration and the distal nerve stumps were examined. Vascular permeabilities to horseradish peroxidase and to [<jats:sup>14<\/jats:sup>C]sucrose increased to day 14, returned toward normal levels by 6 weeks, and continued at near normal levels to 9 months. Perineurial permeabilities to the tracers increased by day 10 and remained elevated at 9 months. Proliferation of perineurial, endothelial, and mast cells occurred between 3 days and 6 weeks, resulting in an increased vascular space (measured with [<jats:sup>3<\/jats:sup>H]dextran) and number of vascular profiles. The perineurium increased in thickness and the mast cells increased in number. This study indicates that during Wallerian degeneration of the frog's sciatic nerve there is (1) a transitory increase in vascular permeability distal to the lesion, that is related to changes within the endoneurium; (2) an irreversible increase in permeability of the perineurium, which begins later than that seen in the endoneurial blood vessels; and (3) proliferation of non\u2010neuronal components in the absence of regenerating neuronal elements. The results indicate that maintenance of vascular integrity does not require the presence of axons in the frog's peripheral nerve, whereas perineurial integrity and barrier function are affected irreversibly by Wallerian degeneration.<\/jats:p>","DOI":"10.1002\/cne.903080410","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T22:35:24Z","timestamp":1104618924000},"page":"650-664","source":"Crossref","is-referenced-by-count":32,"title":["Blood\u2010nerve barrier in the frog during wallerian degeneration: Are axons necessary for maintenance of barrier function?"],"prefix":"10.1002","volume":"308","author":[{"given":"Carole H.","family":"Latker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishena C.","family":"Wadhwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Balbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley I.","family":"Rapoport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1979.tb00644.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00222433"},{"key":"e_1_2_1_4_1","first-page":"236","article-title":"Pathology of experimental spinal cord trauma I. 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