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Quantitative analysis demonstrate that subdiaphragmatic vagotomy, which leaves the cut vagal axons in close proximity to their normal gastric targets, results in significantly less motoneuron loss than cervical vagotomy. Furthermore, the loss of motoneurons after cervical vagotomy can be significantly reduced by transplanting embryonic gastric tissue to the neck of vagotomized neonatal host rats, in the vicinity of the cut axons. The survival effect of transplanted gastric tissue appears specific because control\u2010transplants of embryonic bladder tissue fail to reduce motoneuron death after cervical vagotomy. Injections of the neural tracers Fluoro\u2010Gold and cholera toxin\u2010horseradish peroxidase into gastric transplants labeled surviving motoneurons in cervically vagotomized rats, whereas tracer injections into bladder transplants or into host cervical tissues did not. These results indicate that neonatal vagal motoneurons are capable of making the adjustments necessary to survive axotomy if they have access to gastric target cells. The apparent dependence of injured neonatal vagal motoneurons on gastric tissue offers a new system in which to examine in vivo the trophic interactions between neurons and their targets.<\/jats:p>","DOI":"10.1002\/cne.903130203","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T22:45:31Z","timestamp":1104619531000},"page":"213-226","source":"Crossref","is-referenced-by-count":6,"title":["Access to gastric tissue promotes the survival of axotomized neurons in the dorsal motor nucleus of the vagus in neonatal rats"],"prefix":"10.1002","volume":"313","author":[{"given":"Linda","family":"Rinaman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pat","family":"Levitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1152\/jn.1942.5.4.269","article-title":"A deficiency in the phrenic respiratory discharges parallel to retrograde degeneration","volume":"5","author":"Acheson G. 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