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The present study establishes the anatomical and quantitative baseline of LNGFR immunoreactive (LNGFR\u2010IR) neurons of the entire normal adult female rat and then investigates the temporal course for the re\u2010expression of LNGFR\u2010IR in lumbar motoneurons after either a crush lesion (which is followed by regeneration and reconnection to the muscle) <jats:italic>or<\/jats:italic> a cut lesion with removal of the distal stump (where a neuroma but no reconnection is formed). In the normal adult spinal cord, two types of LNGFR\u2010IR neurons were recognized: (1) small populations of large motoneurons located in the ventral horn mainly in correspondence to the regions of the phrenic, cremasteric and dorsolateral nuclei, and (2) a more numerous and more dorsally located population of small neurons. With a sciatic cut lesion, the number of LNGFR\u2010IR motoneurons at spinal levels L4\u2013L6 rapidly and dramatically increased to a maximum between post\u2010lesion days 1 and 7, apparently involving most axotomized motoneurons of the region, and returned to the baseline level by day 30. With a crush lesion, similar numbers and virtually the same time\u2010course of LNGFR\u2010IR appearance were seen, but the onset of progressive disappearance of LNGFR\u2010IR neurons was delayed by one week, so that at 30 days, the most caudal motoneurons (which are last to reach their target) were still LNGFR\u2010IR. Comparison of these two time courses gives clues to the kind of signals that may be involved in initiating and\/or maintaining the LNGFR response. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.903190208","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T22:58:49Z","timestamp":1104620329000},"page":"285-298","source":"Crossref","is-referenced-by-count":35,"title":["Nerve growth factor receptor immunoreactivity in neurons of the normal adult rat spinal cord and its modulation after peripheral nerve lesions"],"prefix":"10.1002","volume":"319","author":[{"given":"Mario","family":"Rende","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Hagg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marston","family":"Manthorpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Varon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090940210"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-11-03507.1990"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903040407"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902290305"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90540-F"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3008331"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91305-4"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90049-4"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90629-D"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.102.3.830"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90116-U"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90180-8"},{"key":"e_1_2_1_14_1","first-page":"37","article-title":"Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain, Neurosci","volume":"65","author":"Hefti F.","year":"1986","journal-title":"Lett."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/350678a0"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.8.2898"},{"key":"e_1_2_1_17_1","first-page":"111","article-title":"Localization and development of nerve growth factor\u2010sensitive rat basal forebrain neurons and their afferent projections to hippocampus and neocortex","volume":"17","author":"Koh S.","year":"1987","journal-title":"J. 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