{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:31:51Z","timestamp":1787509911109,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":4452,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1992,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The terminations of spinocervical tract fibers in the lateral cervical nucleus (LCN) of the cat were examined with anterogradely transported\n                    <jats:italic>Phaseolus vulgaris<\/jats:italic>\n                    leucoagglutinin (PHA\u2010L) in order to analyze their organization relative to the most medial part and the main body (the lateral two\u2010thirds) of the LCN, which have differential projections and physiological characteristics. Iontophoretic injections of PHA\u2010L in laminae I\u2013V of the spinal dorsal horn yielded dense labeling in somatotopically appropriate regions of the main body of the LCN, and, as seen previously with horseradish peroxidase, additional terminations were present in the medial LCN after injections at either cervical or lumbar spinal levels. The morphological characteristics of the PHA\u2010L labeling in these two parts of the LCN were different. Terminations in the lateral LCN consisted of dense clusters of thick fibers bearing large numbers of boutons. The terminal axons in the medial part of the LCN displayed a reticulated network of longitudinally oriented, fine fibers with well\u2010spaced varicosities. Some of the fine fibers in the medial LCN appeared to be collaterals of thicker fibers that terminated in the lateral LCN.\n                  <\/jats:p>\n                  <jats:p>Injections of PHA\u2010L that were restricted to lamina I resulted in terminal labeling only in the medial LCN. The labeling was more sparse than that observed in the medial LCN after larger dorsal horn injections but displayed the same morphological characteristics. Lamina I terminations were seen in the medial LCN after cervical or lumbar injections on both the ipsilateral and contralateral sides.<\/jats:p>\n                  <jats:p>The PHA\u2010L observations were corroborated by the presence of many retrogradely labeled lamina I cells at both cervical and lumbar spinal levels, following injections of cholera toxin subunit b or rhodamine\u2010labeled microspheres in the medial LCN. In addition, double\u2010immunofluorescent labeling for PHA\u2010L and substance P was performed in a few cases, since substance P immunoreactivity is present in fibers in the medial LCN and also in cell bodies in lamina I; however, very few spinocervical fibers displayed immunoreactivity for both antigens.<\/jats:p>\n                  <jats:p>These observations indicate that the medial part of the LCN receives input from lamina I neurons, and probably from lamina III\u2010V neurons as well, at cervical and lumbar spinal levels. The lamina I input to the medial LCN provides a basis for the small population of nociceptive neurons that differentiate the medial LCN. The lamina I input could also be responsible for the general inhibition of lateral LCN neurons by wide\u2010field noxious stimulation, via activation of GABAergic interneurons in the medial LCN. The present observations in addition indicate that substance P\u2010immunoreactive fibers in the medial LCN probably represent a modulating supra\u2010spinal input. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.903220108","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T18:05:25Z","timestamp":1104602725000},"page":"99-110","source":"Crossref","is-referenced-by-count":24,"title":["Lamina I spinocervical tract terminations in the medial part of the lateral cervical nucleus in the cat"],"prefix":"10.1002","volume":"322","author":[{"given":"A. 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