{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:44:23Z","timestamp":1757540663064},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":4438,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1992,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Water deprivation induces the production of the transcription factor Fos in neurons of the neurohypophysial system. These neurons, which are located primarily in the hypothalamic paraventricular (PVN) and supraoptic nuclei (SON), produce the antidiuretic hormone vasopressin. The present immunocytochemical study has analyzed the distribution of Fos in brain regions involved in osmoregulation and compared the extent of Fos immunoreactivity (Fos\u2010IR) in vasopressin\u2010deficient Brattleboro and normal Long\u2010Evans rats under stimulated and non\u2010stimulated conditions. Rats were osmotically challenged by means of a single intraperitoneal injection of 1.5 M\/L NaCl. Since Fos may be induced by the stress of handling of animals, non\u2010injected and isotonic saline\u2010injected rats were used as controls. Faint nuclear Fos immunostaining was found in the organum vasculosum of the lamina terminalis (OVLT), the median preoptic nucleus (MnPO), subfornical organ (SFO), and SON of non\u2010injected and isotonic saline\u2010injected Brattleboro but not Long\u2010Evans rats. Hypertonic saline injection specifically induced Fos\u2010IR in neurons located in the SFO, OVLT, MnPO, PVN, SON, hypothalamic accessory nuclei (including the nucleus circularis), and arcuate hypothalamic nucleus (Arc) in both Long Evans and Brattleboro rats. No differences in distribution of the induced immunostaining were found between the strains. Stress of handling and (isotonic saline) injection induced Fos\u2010IR in the lateral septal nuclei, central amygdaloid nuclei, medial amygdaloid nucleus, medial preoptic area, the bed nucleus of the stria terminalis, cingulate\u2010 and piriform cortex, the lateral hypothalamic area, ventromedial hypothalamic nucleus, and the habenular nucleus. The data are consistent with a role for Fos in the regulation of vasopressin gene expression during acute hyperosmotic stimulation. In addition, this study demonstrated that during chronic osmotic stimulation, as experienced by homozygous Brattleboro rats, Fos\u2010IR is limited but apparently present constantly and that it increased in these animals following acute osmotic challenge. Our observations suggest that <jats:italic>c<\/jats:italic>\u2010<jats:italic>fos<\/jats:italic> regulatory controls in homozygous Brattleboro rats are different from those in Long\u2010Evans rats. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.903220310","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T03:20:56Z","timestamp":1104549656000},"page":"439-448","source":"Crossref","is-referenced-by-count":22,"title":["Fos\u2010like immunoreactivity in the brain of homozygous diabetes insipidus brattleboro and normal long\u2010evans rats"],"prefix":"10.1002","volume":"322","author":[{"given":"Stephan E. F.","family":"Guldenaar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C.","family":"Noctor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph T.","family":"McCabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp011999"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901660302"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91177-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902960402"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000124040"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(81)90391-8"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90076-1"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90260-X"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(89)90150-7"},{"key":"e_1_2_1_11_1","first-page":"213","article-title":"Analysis of Fos protein complexes and Fos\u2010related antigens by high resolution two\u2010dimensional gel electrophoresis","volume":"1","author":"Franza B. 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