{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:00:50Z","timestamp":1758628850713},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":4377,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1992,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Using scanning and transmission electron microscopy, we studied basic ultrastructure, membrane specializations, and blood\u2010brain barrier properties of the ventral ganglion and abdominal nerves of the last (third) instar larva of a dipteran fly, <jats:italic>Delia platura.<\/jats:italic> Both ganglion and nerves are covered with a non\u2010cellular neural lamella. A monolayer of flattened perineurial cells lies beneath the neural lamella. Perineurial cells contain stores of metabolites and nutrients and these cells extensively interdigitate with one another. An extensive extracellular series of channels pervades perineurial cells. Glial cells beneath the perineurium envelope but do not entwine axons. In a minority of cases, adjacent axons in nerve and neuropil appear to be contiguous without glial intervention. Extensive (pleated) septate junctions with triangular septa are present between perineurial cells. Hemidesmosomes, half desmosomes (a first report for invertebrates), and desmosomes were also observed. Although no tight junctions were discovered, an effective blood\u2010brain barrier exists, and tracer (ionic lanthanum) in no case reached neuronal surfaces. Extracellular tracer halted within the extensive septate junctions between perineurial cells. We postulate that in the absence of tight junctions the functional blood\u2010brain barrier is effected by the septate junctions in the central nervous system of the <jats:italic>Delia<\/jats:italic> larva.<\/jats:p>","DOI":"10.1002\/cne.903240305","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T21:48:25Z","timestamp":1117230505000},"page":"343-352","source":"Crossref","is-referenced-by-count":17,"title":["Fine structure and blood\u2010brain barrier properties of the central nervous system of a dipteran larva"],"prefix":"10.1002","volume":"324","author":[{"given":"Jyh\u2010Lyh","family":"Juang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley D.","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1819","article-title":"Histopathological study of experimental periodontitis in rats\u2013ultrastructures, permeability, immunohistochemistry, and morphometric analysis in both pocket and long junctional epithelial","volume":"83","author":"Abiko Y.","year":"1989","journal-title":"Shikwa\u2010Gakuho."},{"key":"e_1_2_1_3_1","first-page":"213","article-title":"Structure and possible functional role of septate junctions in the ovotestis of a pond snail: inter sertoli junctions","volume":"17","author":"Anelli G.","year":"1985","journal-title":"J. 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