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Their morphology was compared to 13 intact sural nerve hair follicle afferents. Following axotomy, three kinds of morphological abnormalities were observed in the collateral arbors of the 26 afferents that were hair follicle\u2010like. Atrophy with thin stem axons and reduced terminal branch patterns with few boutons was seen in 5 afferents. Sprouting of bouton\u2010containing terminals into lamina I and IIo was found in 8 afferents. Finally, abnormal arborization patterns in the deeper laminae were observed in 29% of the collateral arbors. Changes included the loss in some arbors of a flame\u2010shaped appearance, which is characteristic of hair follicle afferents, atypical branching patterns and ventrally directed axons producing wider and deeper arbors, compared to normal.<\/jats:p><jats:p>Axotomy also caused a disruption of the normal somatotopic organizaiton of sural nerve A beta afferents. This disruption manifested as a variability in the normally mediolaterally restricted terminal sheet, with a consequent loss of the strict somatotopic register in the rostrocaudal direction. Damage to the peripheral axon of A beta primary afferents induces a structural reorganization of their central terminals in the dorsal horn of the spinal cord, which may modify sensory input to the central nervous system.<\/jats:p>","DOI":"10.1002\/cne.903300106","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:44:26Z","timestamp":1104569066000},"page":"65-82","source":"Crossref","is-referenced-by-count":107,"title":["Chronic peripheral nerve section results in a rearrangement of the central axonal arborizations of axotomized A beta primary afferent neurons in the rat spinal cord"],"prefix":"10.1002","volume":"330","author":[{"given":"Peter","family":"Shortland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifford J.","family":"Woolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(85)90006-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(88)90394-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90310-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(87)90135-4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-1305-8"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1113\/jphysiol.1983.sp014644","article-title":"Effects of dorsal root section on spinocervical tract neurons in the cat","volume":"337","author":"Brown A. 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