{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:40:48Z","timestamp":1790750448334,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":4202,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1993,4,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to investigate the topography and subdivisions of the human dorsal motor nucleus of the vagus nerve (10), studies were conducted using cyto\u2010 and chemoarchitectonic (acetylcholinesterase and substance P\u2010like immunoreactivity) and computer reconstruction techniques.<\/jats:p><jats:p>The six brainstems examined were obtained within 17 hours postmortem from adults with no known neurological disorders. Serial sections cut in transverse, sagittal, and coronal planes were stained with cresyl violet, or tested for acetylcholinesterase or substance P. The neurons of the 10 (16,826 \u00b1 967) displayed cyto\u2010 and chemoarchitectonic heterogeneity and could be classified into six types. Types I\u2013V consist of presumed vagal motor neurons (13,802 \u00b1 844), while the remaining type (Type VI) consisted of presumed interneurons (3,024 \u00b1 769). The 10 was subdivided into nine subnuclei grouped regionally into rostral, intermediate, and caudal divisions on the basis of neuronal morphology, cell density, and differential AChE and substance P reactivities. The rostral division contains the dorsorostral (DoR) and the ventrorostral (VeR) subnuclei; the intermediate division contains the rostrointermediate (RoI), dorsointermediate (DoI), centrointermediate (CeI), ventrointermediate (VeI), and caudointermediate (CaI) subnuclei; the caudal division (Ca) is not subdivided. Morphologically, small round or oval cells populate the VeR and VeI. Medium\u2010sized oval cells occur in the DoR, CeI, and Ca, while medium\u2010sized fusiform and multipolar cells are the main features of CaI. Large triangular cells appear mainly in DoI. Glial cells show the highest predilection for CeI, lowest densities in DoI and medial fringe subnucleus (MeF), and intermediate densities in the remaining six subnuclei. VeI showed the strongest AChE reactivity. Although the cell bodies of VeR and DoI are AChE positive, the neuropil (background) is weakly stained. Densely distributed fine granular substance P\u2010like immunoreactivity occurs throughout the entire nucleus, while the intermediate and caudal divisions contain substance P\u2010like\u2010immunoreactive neurons. Three\u2010dimensional computer reconstructions afforded an appreciation of the distinctiveness of the intermediate division (a division that contains the majority of cells) and the caudal division, which displays the lowest density of presumed vagal motoneurons. It is possible that the subnuclei identified herein form functional units innervating specific organs.<\/jats:p>","DOI":"10.1002\/cne.903300203","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:45:26Z","timestamp":1104569126000},"page":"158-182","source":"Crossref","is-referenced-by-count":84,"title":["Dorsal motor nucleus of the vagus nerve: A cyto\u2010 and chemoarchitectonic study in the human"],"prefix":"10.1002","volume":"330","author":[{"given":"Xu\u2010Feng","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"T\u00f6rk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Paxinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090940210"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1978.tb01346.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903040209"},{"key":"e_1_2_1_5_1","first-page":"766","article-title":"Different frequency and temporal response profiles for endocrine pancreatic hormones, gastric acid, and cardiovascular parameters using cervical vagal stimulation (Abstract)","volume":"11","author":"Berthoud H. 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