{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:08:26Z","timestamp":1791158906141,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":4104,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1993,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cadherins are a family of cell surface molecules mediating calcium\u2010dependent cell\u2013cell adhesion in a variety of tissues. More than a dozen cadherins are expressed in the vertebrate brain. To obtain insight into the biological significance of this diversity in cadherin expression, we mapped the expression of N\u2010and R\u2010cadherin in the brain of the developing chicken embryo (days 2\u201319 of incubation) by immunohistochemical and in situ hybridizaiton techniques.<\/jats:p><jats:p>Whereas the expression of N\u2010 and R\u2010cadherin is relatively uniform or weak in early (about 2\u20135 days of incubation) and late development (15 days of incubation to hatching stage), these two molecules are differentially expressed in specific nuclei and fiber tracts between days 6\u201311 of incubation. For example, in the mes\u2010 and diencephalon, one of the tectofugal pathways and its target nuclei, here called the tecto\u2010pretecto\u2010rotundal system, express N\u2010cadherin. R\u2010cadherin is expressed by a different tectofugal system, the tectoisthmic pathway. The other tectofugal systems express neither N\u2010 nor R\u2010cadherin. In addition, a small number of other mes\u2010 and diencephalic nuclei express N\u2010 or R\u2010cadherin. On the basis of these results and experimental evidence from other studies, we speculate that the two cadherins are involved in the formation and segregation of particular functional systems within the vertebrate central nervous system (CNS) by regulating the formation of nuclei, and the pathfinding and\/or the selective fasciculation of neurites.<\/jats:p><jats:p>Apart from neuronal elements, a variety of vascular and ependymal structures also express N\u2010cadherin or R\u2010cadherin, e.g., the parenchymal blood vessels, the choroid plexus, the floor and roof plates, and the ventricular lining. These findings suggest that the two cadherins play a variety of roles during the development of neuronal and nonneuronal epithelial structures throughout CNS development. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.903330307","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:54:09Z","timestamp":1104569649000},"page":"398-416","source":"Crossref","is-referenced-by-count":138,"title":["Differential expression of N\u2010 and R\u2010cadherin in functional neuronal systems and other structures of the developing chicken brain"],"prefix":"10.1002","volume":"333","author":[{"given":"Christoph","family":"Redies","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Engelhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Takeichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901670407"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00309886"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.110.4.1253"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.8.2555"},{"key":"e_1_2_1_6_1","volume-title":"DNA Labelling and Detection. Nonradioactive. Applications Manual","author":"Boehringer","year":"1989"},{"key":"e_1_2_1_7_1","first-page":"475","article-title":"Die Entwicklung der Hirnnerven und ihre zentralen Bahnen","volume":"15","author":"Bok S. T.","year":"1915","journal-title":"Folia neuro\u2010biologica"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902660204"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(90)90108-R"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(90)90178-L"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902230410"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.110.1.97"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902690102"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00218211"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90337-9"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050880104"},{"key":"e_1_2_1_17_1","volume-title":"Antibodies. A Laboratory Manual","author":"Harlow E.","year":"1988"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00225448"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/320447a0"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(87)90119-9"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.106.3.873"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1990.055.01.049"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-12-04653.1988"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900480102"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/978-1-4899-5376-6_16","volume-title":"Comparative Neurobiology of the Optic Tectum","author":"Hunt S. P.","year":"1984"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901700203"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901700204"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90001-4"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90472-O"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90075-B"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1242\/dev.113.3.959","article-title":"Differential expression of R\u2010 and N\u2010cadherin in neural and mesodermal tissues during early chicken development","volume":"113","author":"Inzuka H.","year":"1991","journal-title":"Development"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(66)90006-0"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-09-03118.1990"},{"key":"e_1_2_1_34_1","volume-title":"A Stereotaxic Atlas of the Brain of the Chick (Gallus domesticus)","author":"Kuenzel W. J.","year":"1988"},{"key":"e_1_2_1_35_1","first-page":"361","article-title":"The ontogenic development of the diencephalic centres in a bird's brain (chick) and comparison with the reptilian and mammalian diencephalon","volume":"71","author":"Kuhlenbeck H.","year":"1937","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_36_1","volume-title":"Spinal Cord and Deuterencephalon","author":"Kuhlenbeck H.","year":"1975"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490320209"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(90)90209-2"},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/334062a0","article-title":"Guidance of optic nerve fibres by N\u2010cadherin adhesion molecules","volume":"334","author":"Matsunga M.","year":"1988","journal-title":"Nature"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90077-3"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2762814"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.113.4.893"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.107.3.1177"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90114-6"},{"key":"e_1_2_1_45_1","first-page":"496","volume-title":"Histologie du syst\u00e8me nerveux de l'homme and des vert\u00e9br\u00e9s","author":"Ramon y Cajal S.","year":"1911"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/1044-5765(91)90046-Q"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90291-7"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.8.2709"},{"key":"e_1_2_1_49_1","doi-asserted-by":"crossref","unstructured":"Redies C. andM.Takeichi(1993a)N\u2010 and R\u2010cadherin expression in the optic nerve of the chicken embryo. Glia (in press).","DOI":"10.1002\/glia.440080304"},{"key":"e_1_2_1_50_1","doi-asserted-by":"crossref","unstructured":"Redies C. andM.Takeichi(1993b)Expression of N\u2010cadherin mRNA during development of the mouse brain. Dev. Dynamics (in press).","DOI":"10.1002\/aja.1001970104"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-09-03525.1992"},{"key":"e_1_2_1_52_1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1152\/physrev.1988.68.3.819","article-title":"Cell adhesion molecules in vertebrate neural development","volume":"68","author":"Rutishauser U.","year":"1988","journal-title":"Physiol. Rev."},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903100208"},{"key":"e_1_2_1_54_1","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1242\/dev.116.4.1011","article-title":"Local and transient expression of E\u2010cadherin involved in mouse embryonic brain morphogenesis","volume":"116","author":"Shimamura K.","year":"1992","journal-title":"Development"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(92)90132-Z"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.50.4.703"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.2.4.261"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.102.4.639"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2006419"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1990.055.01.033"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(84)90057-5"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90366-8"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90207-3"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903050310"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.903330307","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.903330307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T23:23:57Z","timestamp":1698276237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.903330307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7,15]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,7,15]]}},"alternative-id":["10.1002\/cne.903330307"],"URL":"https:\/\/doi.org\/10.1002\/cne.903330307","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7,15]]}}}