{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:57:56Z","timestamp":1758124676514},"reference-count":68,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":4042,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1993,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The 75 kDa protein nerve growth factor receptor [NGFr(p75)] is a neurotrophin receptor that is able to bind different members of the neurotrophin family of molecules implicated in affecting neruronal survival. Here we describe the light microscopic distribution of NGFr(p75)\u2010immunoreactivity (IR) within the feline trigeminal brainstem sensory nuclear complex and trigeminal ganglion of normal adult subjects and in subjects 10 and 30 days following retrogasserian rhizotomy. Within the trigeminal ganglion of normal subjects, numerous fibers and most of the neuronal cell bodies showed NGFr(p75)\u2010IR that varied in intensity, while cells and fibers with NGFr(p75)\u2010IR were less numerous within the mesencephalic trigeminal nucleus. Within the main sensory and spinal trigeminal nuclei, NGFr(p75)\u2010IR formed a reproducible pattern that varied between the different subnuclei. The NGFr(p75)\u2010IR consisted both of dense pockets and a low level NGFr(p75)\u2010IR that was selective to the trigeminal neuropil. Following rhizotomy, most of the NGFr(p75)\u2010IR was lost from the main sensory and spinal trigeminal nuclei, except in regions where the upper cervical roots and cranial nerves VII, IX, and X project. In contrast, examination of the central root that was still attached to the trigeminal ganglion showed increased NGFr(p75)\u2010IR in fibers and supporting cells, as did the motor root within the peripheral mandibular division. These results indicate that the majority of the NGFr(p75)\u2010IR within the main sensory and spinal trigeminal nuclei originates from primary trigeminal afferents and that retrogasserian rhizotomy leads to an up\u2010regulation of NGFr(p75)\u2010IR in the part of the central root that is contiguous with the ganglion. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.903350311","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:01:56Z","timestamp":1104570116000},"page":"425-436","source":"Crossref","is-referenced-by-count":14,"title":["Nerve growth factor receptor (p75)\u2010immunoreactivity in the normal adult feline trigeminal system and following retrogasserian rhizotomy"],"prefix":"10.1002","volume":"335","author":[{"given":"Michael A.","family":"Henry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesnick E.","family":"Westrum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Bothwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lonnie R.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901840303"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.16.7106"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"15509","DOI":"10.1016\/S0021-9258(17)42578-6","article-title":"Association of 125I\u2010NGF with PC12 pheochromocytoma cells. 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