{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:03:01Z","timestamp":1770501781917,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":4019,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1993,10,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prior studies indicate that neonatal nerve injury kills many trigeminal (V) first\u2010 and second\u2010order cells, and interrupts pattern formation in the brainstem and cerebral cortex. Yet it is not known whether effects upon cell survival and pattern formation are causally related. To determine whether axotomized V ganglion cells can be rescued by an exogenous trophic agent, rats received 5 mg\/kg of nerve growth factor (NGF) prior to, and every day after, infraorbital nerve section on the day of birth until sacrifice on postnatal day (PND) 1, 3, 5, 7, or 14. Other animals received identical lesions without NGF. Ganglion cell numbers were significantly reduced by PNDl in pups not given NGF, while NGF\u2010treated rats displayed no significant cell loss through PND7. However, NGF did not permanently rescue V neurons because ganglion cell numbers were reliably reduced by PND14.<\/jats:p><jats:p>Cell numbers in V nucleus principalis were reduced by PNDl in pups not given NGF, while NGF\u2010treated animals displayed no cell loss through PND14. NGF's rescue of second\u2010order cells is probably an indirect effect of NGF actions upon V ganglion cells because, in other newborns, NGF failed to maintain principalis cells after direct lesion of the left V ganglion.<\/jats:p><jats:p>To determine whether preventing cell death permits whisker\u2010related pattern formation, other rats also received NGF prior to and after infraorbital nerve section at birth. After 3\u201314 days, patterns were assessed in the brainstem and cortex with cytochrome oxidase histochemistry and serotonin immunocytochemistry. Whisker\u2010related patterns failed to develop as in cases not given NGF.<\/jats:p><jats:p>These data indicate that communication with the periphery is necessary for the maintenance of central whisker\u2010related patterns. They also suggest that V ganglion cells can be rescued, albeit temporarily, from rapid injury\u2010induced death by NGF, thereby delaying injury\u2010induced cell death in nucleus principalis. However, the mechanism(s) responsible for injury\u2010induced pattern alterations in the developing V system remains to be elucidated. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.903360207","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:03:40Z","timestamp":1104570220000},"page":"243-260","source":"Crossref","is-referenced-by-count":25,"title":["NGF Augmentation rescues trigeminal ganglion and principalis neurons, but not brainstem or cortical whisker patterns, after infraorbital nerve injury at birth"],"prefix":"10.1002","volume":"336","author":[{"given":"Theodore A.","family":"Henderson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Rhoades","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol A.","family":"Bennett\u2010Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pat A.","family":"Osborne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene M.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark F.","family":"Jacquin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(91)90089-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90425-N"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/1.5.380"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1523\/JNEUROSCI.09-04-01263.1989","article-title":"Effect of NGP on the survival of rat retinal ganglion cells following optic nrve section","volume":"9","author":"Carmignoto G.","year":"1989","journal-title":"J. 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