{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T22:38:13Z","timestamp":1769380693610,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":4012,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1993,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The carotid body is an arterial chemoreceptor organ sensitive to blood levels of O<jats:sub>2<\/jats:sub>, CO<jats:sub>2<\/jats:sub> and pH. The present immunocytochemical and neurochemical study has demonstrated the presence of an extensive plexus of nitric oxide (NO)\u2010synthesizing nerve fibers in this organ. These nitric oxide synthase (NOS)\u2010containing axons are closely associated with parenchymal type I cells and with blood vessels in the carotid body. Denervation and retrograde tracing experiments have revealed that these fibers arise from NOS\u2010immunoreactive and nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase\u2010positive neuronal cell bodies located in the petrosal ganglion and the carotid body, and dispersed along the glossopharyngeal and carotid sinus nerves (CSN). Within the petrosal ganglion, these neurons are topographically segregated from the catecholaminergic cells, and they contain the neuropeptide, substance P. NOS\u2010positive autonomic microganglial cells in the carotid body and CSN also exhibit choline acetyltransferse (ChAT) immunoreactivity. Our results suggest that nitric oxide may be a novel neuronal messenger in the mammalian carotid body involved in the modulation of chemosensory transduction and transmission in this organ. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.903360308","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:05:19Z","timestamp":1104570319000},"page":"419-432","source":"Crossref","is-referenced-by-count":88,"title":["Neurons synthesizing nitric oxide innervate the mammalian carotid body"],"prefix":"10.1002","volume":"336","author":[{"given":"Z.\u2010Z.","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. S.","family":"Bredt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Fidone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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