{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:16:28Z","timestamp":1789877788756,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":3854,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1994,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The olfactory system is a unique part of the central nervous system since it retains neuronal turnover and regenerative capacities in adulthood. Thus it provides an ideal model to study plasticity of membrane moities involved in cell\u2010cell interactions. One structure particularly involved in cell\u2010cell interaction is the tight junction, which establishes polarization of epithelial cells and creates diffusion barriers to paracellular passages. ZO\u20101 is a phosphoprotein peripherally associated with tight junctions. We have studied expression of ZO\u20101 protein in the developing and adult olfactory system of the mouse in order to get information about the localization and developmental expression of this tight junction component. ZO\u20101 expression has also been determined in cell cultures of olfactory bulbs.<\/jats:p><jats:p>ZO\u20101 was present in the olfactory placode prior to formation of tight junctions. ZO\u20101 was localized in the developing and mature olfactory epithelium at heterotypic contacts between supporting cells and olfactory neurons as well as at homotypic contacts between both these cell types. Confocal microscopy showed quantitative differences in the ZO\u20101 expression among different olfactory dendrites. In the olfactory nerves ZO\u20101 immunolabeling was detectable between olfactory ensheathing cells. From the seventh postnatal day ZO\u20101 immunolabeling was detected at the mitral cell layer of the bulb on cells tentatively identified as oligodendrocytes. Myelinated tracts of the bulb were ZO\u20101 negative. Cell cultures of olfactory bulbs showed ZO\u20101 immunoreaction, mostly localized on glial fibrillary acidic protein (GFAP)\u2010positive cells.<\/jats:p><jats:p>Our results provide further evidence that ZO\u20101 serves functions unrelated to the tight junction complex and indicate molecular heterogeneity of these cell\u2010cell contacts.<\/jats:p>","DOI":"10.1002\/cne.903410402","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:19:47Z","timestamp":1104571187000},"page":"433-448","source":"Crossref","is-referenced-by-count":37,"title":["Expression of the tight junction protein ZO\u20101 in the olfactory system: Presence of ZO\u20101 on olfactory sensory neurons and glial cells"],"prefix":"10.1002","volume":"341","author":[{"given":"Fernando","family":"Miragall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"De Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Dermietzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"77","volume-title":"Tight Junctions","author":"Anderson J. 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