{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:05:03Z","timestamp":1760954703913},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":3807,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1994,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study shows that the fish optic nerve, which is able to regenerate after injury, contains myelin\u2010associated growth inhibitors similar to the growth inhibitors present in mammalian central nervous system (CNS) myelin. The ability of nerves to regenerate was previously correlated with the ability of sections from these nerves to support neuronal attachment to and axonal growth in vitro. Thus neuroblastoma cells or embryonic neurons became attached to and grew axons on sections of rat sciatic nerve or fish optic nerve, which are spontaneously regenerating systems, but not on sections of rat optic nerve, a nongenerating system. Failure of the latter to support axonal growth has been attributed, at least in part, to growth inhibitors. Recently it was shown that adult neurons, which differ in their growth requirement from embryonic neurons, are unable to extend neurites on sections of normal sciatic nerve but are able to extend neurites on sections of sciatic nerve that was injured prior to its excision. We found a similar in the fish optic nerve, i.e. that the nerve is normally not permissive to growth of adult retinal axons but becomes growth permissive after injury. The nonpermissiveness of the normal fish optic nerve was found to correlate with the presence of myelin\u2010associated growth\u2010inhibitory molecules. This inhibitory activity of fish myelin was neutralized by IN\u20101 antibodies, known to neutralize rat myelin growth inhibitors apparently similar or even identical to those of rat, but possibly present in lower amounts than in the rat. Results are discussed with respect to the possibility that fish optic nerve, like the rat sciatic regeneration of adult neurons. Such changes might include elimination or neutralization of growth inhibitors. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.903430205","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:29:04Z","timestamp":1104571744000},"page":"237-246","source":"Crossref","is-referenced-by-count":35,"title":["Presence of growth inhibitors in fish optic nerve myelin: Postinjury changes"],"prefix":"10.1002","volume":"343","author":[{"given":"T.","family":"Sivron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6171034"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1523\/JNEUROSCI.11-03-00626.1991","article-title":"Growth of regenerating goldfish axons is inhibited by rat oligodendrocytes and CNS myelin but not by goldfish optic nerve tract oligodendrocyte\u2010like cells and fish CNS myelin","volume":"11","author":"Bastmeyer M.","year":"1991","journal-title":"J. Neurosci."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1992.tb00867.x"},{"key":"e_1_2_1_5_1","first-page":"249","article-title":"A rapid sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein\u2010dye binding","volume":"72","author":"Bradford M.","year":"1972","journal-title":"Anal. Biochem."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-02-00610.1987"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1083\/jcb.106.4.1281","article-title":"Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading","volume":"108","author":"Caroni P.","year":"1988","journal-title":"J. Cell Biol."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90212-7"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90335-9"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(90)90085-T"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440040403"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1523\/JNEUROSCI.01-08-00793.1981","article-title":"The growth and organization of the optic nerve and tract in juvenile and adult goldfish","volume":"1","author":"Easter S. S.","year":"1981","journal-title":"J. Neurosci."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(81)90016-9"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.10.4913"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8100369"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.12.5442"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)91017-1"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-044276-8.50013-8"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb01869.x"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00965529"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-11-03030.1985"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1973.tb00277.x"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901760304"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-185X.1979.tb00871.x"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2799387"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0006-8993(76)90714-9","article-title":"Explant culture of adult goldfish retina: Effect of prior optic nerve crush","volume":"118","author":"Landerth G. E.","year":"1976","journal-title":"Brain Res."},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0006-8993(79)90194-X","article-title":"Explant culture of adult goldfish retina: A model for the study of CNS regeneration","volume":"161","author":"Landerth G. E.","year":"1979","journal-title":"Brain Res."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902980304"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb03963.x"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90399-2"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901680202"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/BF01191504","article-title":"Myelination of regenerated axons in goldfish optic nerve by Schwann cells","volume":"21","author":"Nona S. N.","year":"1928","journal-title":"J. Neurocytol."},{"key":"e_1_2_1_33_1","volume-title":"Degeneration and Regeneration of the Nervous System","author":"Ram\u00f3n y Cajal S.","year":"1928"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1002\/j.1460-2075.1990.tb07425.x","article-title":"A plasminogen activator is induced during goldfish optic nerve regeneration","volume":"9","author":"Salle\u00e1s F. J.","year":"1990","journal-title":"EMBO J."},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.19.6934"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.09-04-01126.1989"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/343269a0"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-07-02381.1988"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.16.030193.003025"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3983646"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440030406"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440040606"},{"key":"e_1_2_1_43_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1086\/physzool.21.4.30152014","article-title":"Patterning of central synapses in regeneration of the optic nerve in teleosts","volume":"23","author":"Sperry R. W.","year":"1948","journal-title":"Physiol. Zool."},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1990.tb00403.x"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67801-1_1"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.903430205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.903430205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T07:48:48Z","timestamp":1698133728000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.903430205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,5,8]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,5,8]]}},"alternative-id":["10.1002\/cne.903430205"],"URL":"https:\/\/doi.org\/10.1002\/cne.903430205","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,5,8]]}}}