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Using a polyclonal antiserum raised against chick axonin\u20101, which shares 75% of its sequence with TAG\u20101 of the rat, we have mapped the distribution of TAG\u20101\/axonin\u20101 throughout the developing nervous system of the mouse.<\/jats:p><jats:p>Although absent from proliferating neuroepithelia and from non\u2010neuronal cells, immunoreactivity for TAG\u20101\/axonin\u20101 is expressed by stage\u2010specific subpopulations of differentiating neurons from embryonic day 10 to postnatal day 15. It stains their axons and the surface of their parent somata during the early phases of axogenesis. In agreement with a putative role of TAG\u20101\/axonin\u20101 as an axon\u2010bound growth substrate, immunoreactivity is found in developing spinal and cranial nerves, in corticothalamic projections, as well as in subsets of fasciculating long projecting tracts of the central nervous system, such as the dorsal funiculi of the spinal cord, the lateral olfactory and optic tracts, the fasciculus retroflexus, and the predorsal bundle. High levels of immunoreactivity characterise the development of the cerebellar molecular layer, the corpus callosum, anterior and hippocampal commissure, and of crossed projections in the spinal cord and at several levels of the brainstem.<\/jats:p><jats:p>Intense immunoreactivity in fine collaterals of cutaneous afferents, including their growth cones that are in contact with the embryonic skin, suggests a role of TAG\u20101\/axonin\u20101 in target recognition. While staining is weak on the somata of radially migrating neurons such as cortical neurons and cerebellar granule cells, strong immunoreactivity is associated with neural somata and processes of the three tangential migrations that form the precerebellar nuclei, indicating a possible involvement of TAG\u20101\/axonin\u20101 in contacts between these neurons and the processes they migrate upon. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.903450102","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:35:07Z","timestamp":1104572107000},"page":"1-32","source":"Crossref","is-referenced-by-count":133,"title":["Distribution of TAG\u20101\/Axonin\u20101 in fibre tracts and migratory streams of the developing mouse nervous system"],"prefix":"10.1002","volume":"345","author":[{"given":"David P.","family":"Wolfer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Henehan\u2010Beatty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther T.","family":"Stoeckli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sonderegger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Peter","family":"Lipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901820512"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-68479-1_1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902310103"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902310104"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902570403"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902570404"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902570405"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902750304"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902750305"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902840405"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902830207"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1523\/JNEUROSCI.13-11-04898.1993","article-title":"Preganglionicautonomic motor neurons display normal translocation patterns in slice cultures of embryonic rat spinal cord","volume":"13","author":"Barber R. 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