{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:58:03Z","timestamp":1790485083565,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":3609,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1994,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To determine the relative contributions of transthalamic cerebellar and pallidal projections to the primary motor cortex (M1) of owl monkeys, we examined the thalamic labeling resulting from injections of fluorescent tracers and wheatgerm agglutinin\/horseradish peroxidase conjugate (WGA\u2010HRP) into regions of M1 identified by intracortical microstimulation. Injections were placed in the major somatotopic divisions of M1 (the hindlimb, trunk, forelimb, and face representations) and in the caudal and rostral M1 subareas. In most cases, we injected several differentiable tracers into different parts of M1. Our results indicate that the strongest connections of M1 are with subdivisions of the ventral lateral thalamus (VL); other connections are mainly with intralaminar nuclei (the central lateral, paracentral, and center median nuclei) and the reticular nucleus. Most projections are reciprocal and topographically organized. M1 is strongly connected with the principal (VLp), medial (VLx), and anterior (VLa) subdivisions of the VL complex but has at most weak connections with the dorsal division (VLd). Each of the major somatotopic divisions of M1 is connected with an anteroposteriorly elongated territory within the VL complex. The connections are somatotopically organized such that the M1 hindlimb representation is connected with a band of cells in the lateral and anterior portions of the VL complex (spanning VLa and VLp), whereas the trunk, forelimb, and face representations are connected with successively more medially and posteriorly situated cell bands (spanning VLa, VLp, and VLx). There is some degree of overlap between the somatotopic territories within VL, although the absence of double\u2010labeled cells in cases with injections of adjacent somatotopic divisions of M1 suggests that individual thalamic neurons project to single somatotopic regions.<\/jats:p><jats:p>In addition to somatotopic differences, the connections of the caudal and rostral subdivisions of M1 differ to some extent. Caudal M1 is connected most strongly with VLp, a target of cerebellar projections, but it is also connected with VLa, which receives pallidal inputs. In complementary fashion, rostral M1 is most strongly connected with VLa, but it is also connected with VLp. VLx, a target of cerebellar projections, has significant connections with both caudal and rostral M1. These results indicate that all parts of M1 are influenced by both the cerebellum and globus pallidus in owl monkeys, as has been suggested in some recent studies of macaque monkeys. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.903490405","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T23:19:38Z","timestamp":1104621578000},"page":"558-582","source":"Crossref","is-referenced-by-count":78,"title":["Thalamic connections of the primary motor cortex (M1) of owl monkeys"],"prefix":"10.1002","volume":"349","author":[{"given":"Iwona","family":"Stepniewska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Preuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon H.","family":"Kaas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"7","article-title":"Relationships of precentral, premotor and prefrontal cortex to the mediodorsal and intralaminar nuclei of the monkey thalamus","volume":"40","author":"Akert K.","year":"1980","journal-title":"Acta Neurobiol. Exp."},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/0304-3940(79)91581-7","article-title":"Afferent connections of the mediodorsal thalamic nucleus in the rabbit studied with horseradish peroxidase technique","volume":"2","author":"Arikuni T","year":"1979","journal-title":"Neurosci. Lett."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(83)90014-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(83)90015-2"},{"key":"e_1_2_1_6_1","first-page":"947","volume-title":"Handbook of Physiology, The, Nervous System II","author":"Carpenter M. B.","year":"1981"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)91113-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902920106"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902990103"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(69)90180-2"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238104"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91688-D"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00325634"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902590309"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)91423-9"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902470303"},{"key":"e_1_2_1_17_1","first-page":"395","article-title":"Projections of the precentral motor cortex and other cortical areas of the frontal lobe to the subthalamic nucleus in the monkey","volume":"33","author":"Hartmann\u2010von Monakow K.","year":"1978","journal-title":"Exp. Brain Res."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901830304"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-09-02644.1991"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902360304"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902620303"},{"key":"e_1_2_1_22_1","first-page":"252","article-title":"Afferent connection of the cat's thalamic mediodorsal nucleus","volume":"10","author":"Irle E.","year":"1982","journal-title":"Neurosci. Lett."},{"key":"e_1_2_1_23_1","first-page":"29","article-title":"Cortical and subcortical including sensory related afferents to the thalamic mediodorsal nucleus of the cat","volume":"25","author":"Irle E.","year":"1984","journal-title":"J. Hirnforsch."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901600203"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-1749-8"},{"key":"e_1_2_1_26_1","series-title":"Ciba Foundation Symposium 132","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-1-4615-6616-8","volume-title":"Motor Areas of the Cerebral Cortex","author":"Jones E. G.","year":"1987"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901540402"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901830410"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)91341-6"},{"key":"e_1_2_1_30_1","first-page":"421","volume-title":"Comparative Primate Biology, Vol. 4: Neurosciences","author":"Kaas J. H.","year":"1988"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236173"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901690302"},{"key":"e_1_2_1_33_1","first-page":"105","article-title":"Topographical organization of frontal association cortex afferents originating in ventral thalamic nuclei in dog brain","volume":"46","author":"Kosmal A.","year":"1986","journal-title":"Acta Neurobiol. Exp."},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90424-8"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(91)90116-G"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(67)90004-2"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902540403"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902800311"},{"key":"e_1_2_1_39_1","first-page":"203","article-title":"Ideas of a new anatomy of the thalamus","volume":"8","author":"Mehler W. R.","year":"1971","journal-title":"J. Psychiatr."},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000102797"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902520107"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90698-4"},{"key":"e_1_2_1_43_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000100589","article-title":"Cortical connections of the motor thalamic nuclei in Japanese monkey, Macaca fuscata","volume":"60","author":"Nakano K.","year":"1993","journal-title":"Stereotact. Funct. Neurosurg."},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00248759"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(66)90103-X"},{"key":"e_1_2_1_46_1","volume-title":"The Thalamus of the Macaca mulatta","author":"Olszewski J.","year":"1952"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902880408"},{"key":"e_1_2_1_48_1","first-page":"375","article-title":"The thalamic territory of cerebellar afferents and the lateral region of the thalamus of the macaque in stereotaxic ventricular coordinates","volume":"18","author":"Percheron G.","year":"1977","journal-title":"J. Hirnforsch."},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900770105"},{"key":"e_1_2_1_50_1","first-page":"103","article-title":"Organization and adaptability of muscle representation in primary motor cortex","volume":"22","author":"Sanes J. N.","year":"1992","journal-title":"Exp. Brain Res."},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-02-00539.1984"},{"key":"e_1_2_1_52_1","volume-title":"Nonparametric Statistics for the Behavioral Sciences","author":"Siegel S.","year":"1988"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901900406"},{"key":"e_1_2_1_54_1","first-page":"23","article-title":"Differential projection from the motor and limbic cortical regions to the mediodorsal thalamic nucleus in the dog","volume":"49","author":"Stepniewska I.","year":"1986","journal-title":"Acta Neurobiol. Exp."},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903300207"},{"key":"e_1_2_1_56_1","first-page":"1211","article-title":"Thalamic connections of the dorsal and ventral premotor areas in owl monkeys","volume":"19","author":"Stepniewska I.","year":"1993","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_57_1","doi-asserted-by":"crossref","unstructured":"Stepniwska I. T. M. Preuss andJ. H.Kaas(1994) Architectonic subdivisions of the motor thalamus in owl monkey (Aotus trivirgatus): Comparison of Nissl AChE and CO patterns.J. Comp. Neurol.","DOI":"10.1002\/cne.903490404"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90402-3"},{"key":"e_1_2_1_59_1","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1152\/jn.1976.39.5.1020","article-title":"Anatomical analysis of ventrolateral thalamic input to primate motor cortex","volume":"39","author":"Strick P. L.","year":"1976","journal-title":"J. Neurophysiol."},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90035-5"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1982.48.1.139"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1982.48.1.150"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1980.44.3.532"},{"key":"e_1_2_1_64_1","volume-title":"The Primate Thalamus","author":"Walker A. E.","year":"1938"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237670"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237671"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90728-5"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(83)90376-X"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236805"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.903490405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.903490405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T07:44:53Z","timestamp":1698133493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.903490405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,11,22]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,11,22]]}},"alternative-id":["10.1002\/cne.903490405"],"URL":"https:\/\/doi.org\/10.1002\/cne.903490405","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,11,22]]}}}