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We examined the olfactory bulb transplant at the ultrastructural level to determine whether synaptic contacts are reestablished between host olfactory neurons and donor olfactory bulb. Mature rats that, as neonates, had received embryonic olfactory bulb transplants following olfactory bulb removal were studied. An antibody specific for olfactory marker protein was used to identify the primary olfactory neurons; it was bound by a gold\u2010conjugated secondary antibody for visualization. To preserve the antigenicity of the olfactory marker protein for immunolabeling, Lowicryl K4M hydrophilic resin was used. Synaptic contacts were unmistakable between labeled axons of host olfactory neurons and unlabeled processes within glomerulus\u2010like areas of the transplanted olfactory bulb. The surrounding neuropil contained other elements similar to those found in normal tissue, including synaptic contacts between unlabeled profiles. We clearly show that the transplanted olfactory bulb exhibits sufficient plasticity to form an array of normal synaptic contacts, including the contacts from host primary olfactory neurons. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.903520204","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T22:13:27Z","timestamp":1104617607000},"page":"203-212","source":"Crossref","is-referenced-by-count":7,"title":["Host primary olfactory axons make synaptic contacts in a transplanted olfactory bulb"],"prefix":"10.1002","volume":"352","author":[{"given":"B.L.","family":"Goheen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.N.","family":"Kott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.L.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.E.","family":"Westrum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,10]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237470"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902850207"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1060050403"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(80)90062-7"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0168-0102(88)90036-3","article-title":"Heterotopically transplanted embryonic olfactory bulb projection neurons form selective and appropriate axonal projections over considerable distances in adult host brains","volume":"5","author":"Fuji M.","year":"1988","journal-title":"Neurosci. 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