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To address this question, we used an antibody directed against the C\u2010terminal portion of the rat substance P receptor to examine the cellular distribution of the receptor in spinal cord neurons. In a previous study, we reported that the substance P receptor decorates almost the entire dendritic and somatic surface of a subpopulation of spinal cord neurons. In the present study we have taken advantage of this labeling pattern to identify morphologically distinct subpopulations of substance P receptorimmunoreactive neurons throughout the rostral\u2010caudal extent of the spinal cord. We observed a dense population of fusiform substance P receptor\u2010immunoreactive neurons in lamina I at all segmental levels. Despite having the highest concentration of substance P terminals, the substantia gelatinosa (lamina II) contained almost no substance P receptor\u2010immunoreactive neurons. Several distinct populations of substance P receptor\u2010immunoreactive neurons were located in laminae III\u2010V; many of these had a large, dorsally directed dendritic arbor that traversed the substantia gelatinosa to reach the marginal layer. Extensive labeling was also found in neurons of the intermediolateral cell column. In the ventral horn, we found that labeling was associated with clusters of motoneurons, notably those in Onuf's nucleus in the sacral spinal cord. Finally, we found no evidence that primary afferent fibers express the substance P receptor. These results indicate that relatively few, but morphologically distinct, subclasses of spinal cord neurons express the substance P receptor. The majority, but not all, of these neurons are located in regions that contain neurons that respond to noxious stimulation. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/cne.903560302","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T22:25:42Z","timestamp":1104618342000},"page":"327-344","source":"Crossref","is-referenced-by-count":214,"title":["Morphological characterization of substance P receptor\u2010immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalis"],"prefix":"10.1002","volume":"356","author":[{"given":"Jessica L.","family":"Brown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hantao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Maggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Vigna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Mantyh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan I.","family":"Basbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,10]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb33122.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1139\/y90-166"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(88)90140-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901840208"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(79)96148-2"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(83)90215-X"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901940407"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(86)90141-5"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1523\/JNEUROSCI.05-06-01653.1985","article-title":"Autoradiographic localization and characterization of spinal cord substance P binding sites: High densities in sensory, autonomic, phrenic, and Onuf's motor nuclei","volume":"5","author":"Charlton C. 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