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The immunostaining with PGP 9. 5 antibody clearly demonstrated chronological alterations of the distribution and ultrastructure of the Ruffini endings during postnatal development. At 1 day after birth, the PGP 9. 5 positive nerve terminals contained a few mitochondria and vesicles immunonegative for PGP 9. 5. Dendritic terminals appeared at 4 days after birth, with a small number of expanded or bulbous portions. These expanded portions possessed morphological features similar to those of the growth cone: several mitochondria and various kinds of vesicles. Typical Ruffini endings with dendritic ramification and expanded portions appeared 7\u201311 days after birth. At this stage, parts of the axon terminals extended through the slits of Schwann cell covering and formed finger\u2010like projections called axonal spines. These Ruffini endings increased dramatically in number after 24\u201326 days and were identical in density and morphology to those seen in adult rats. After the commencement of the occlusion between the incisors, the number of large mitochondria increased, in contrast to the decrease of the vesicles in the axon terminals. Moreover, the axonal spines increased both in number and in length. Thus, the periodontal nerve endings showed stage\u2010specific morphological features intimately related in timing to tooth eruption and occlusion. Functional stimuli possibly contribute to the final differentiation and maturation of the periodontal Ruffini endings. \u00a9 1995 Wiley\u2010Liss Inc.<\/jats:p>","DOI":"10.1002\/cne.903620409","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T07:26:02Z","timestamp":1104564362000},"page":"551-564","source":"Crossref","is-referenced-by-count":49,"title":["Postnatal development of periodontal ruffini endings in rat incisors: An immunoelectron microscopic study using protein gene product 9.5 (PGP 9.5) antibody"],"prefix":"10.1002","volume":"362","author":[{"given":"Kuniko","family":"Nakakura\u2010Ohshima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeyasu","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiro","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,10]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"3","volume-title":"Handbook of Sensory Physiology II","author":"Andrea K. 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