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This leads to thinning of the cortical wall proceeding from the endosteum, a process sometimes called \u2018trabecularisation\u2019. In this paper, we investigate the influence of the nonuniform distribution of bone surface within bone tissue for osteoporotic bone losses. We use a spatio\u2010temporal computational model of bone remodelling in which microstructural changes of bone tissue are represented by a phenomenological relationship between bone specific surface and bone porosity. The simulation of an osteoporotic condition by our model shows that the evolution of bone porosity within a bone cross section is significantly influenced by the nonuniform availability of bone surface. Greater bone loss occurs near the endocortical wall, leading to cortical wall thinning and to an expansion of the medullary cavity similar to cross\u2010sectional observations from human femur midshafts. Our model suggests that the rate of cortical wall thinning is fast\/slow in the presence\/absence of an adjacent trabecular or trabecularised bone compartment. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cnm.2567","type":"journal-article","created":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T20:44:12Z","timestamp":1372711452000},"page":"1307-1322","source":"Crossref","is-referenced-by-count":36,"title":["Endocortical bone loss in osteoporosis: the role of bone surface availability"],"prefix":"10.1002","volume":"29","author":[{"given":"Pascal R.","family":"Buenzli","sequence":"first","affiliation":[{"name":"School of Mathematical Sciences Monash University  VIC 3800 Australia"},{"name":"Engineering Computational Biology Group The University of Western Australia  WA 6009 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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