{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:48:10Z","timestamp":1780508890013,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Clarendon Fund (University of Oxford, UK)"},{"name":"National Science Foundation Graduate Research Fellowship (USA)"},{"name":"Whitaker International Fellowship (USA)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Numer Methods Biomed Eng"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study investigated whether increased loading (representing obesity) in the extended knee and flexed knee led to increased stresses in areas of typical medial and lateral osteoarthritis cartilage lesions, respectively. We created two paired sets of subject\u2010specific finite element models; both sets included models of extended knees and of flexed knees. The first set represented normal loading; the second set represented increased loading. All other variables were held constant. The von Mises stresses and contact areas calculated on the tibial cartilage surfaces of the paired models were then compared.<\/jats:p><jats:p>In the extended knee models, applying a larger load led to increased stress in the anterior and central regions of the medial tibial cartilage. These are the typical locations of medial osteoarthritis cartilage lesions. Therefore, the results support that increased loading in the extended knee may result in medial osteoarthritis.<\/jats:p><jats:p>In the flexed knee models, applying a larger load increased stress in the anterior and central regions of the lateral tibial cartilage. Lateral osteoarthritis cartilage lesions typically occur centrally and posteriorly. Therefore, these results do not support our hypothesis. Shear stress was increased in areas of typical lateral lesions, however, and should be investigated in future studies. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cnm.2740","type":"journal-article","created":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T03:42:58Z","timestamp":1438400578000},"source":"Crossref","is-referenced-by-count":3,"title":["Does increasing applied load lead to contact changes indicative of knee osteoarthritis? A subject\u2010specific FEA study"],"prefix":"10.1002","volume":"32","author":[{"given":"Jennifer L.","family":"Boyd","sequence":"first","affiliation":[{"name":"Department of Engineering Science University of Oxford  Oxford UK"},{"name":"Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy B.","family":"Zavatsky","sequence":"additional","affiliation":[{"name":"Department of Engineering Science University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harinderjit S.","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of Bath  Bath UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204763"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20880"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453679209154722"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164702320155347"},{"issue":"4","key":"e_1_2_7_6_1","first-page":"582","article-title":"Anteromedial osteoarthritis of the knee","volume":"73","author":"White SH","year":"1991","journal-title":"Journal of Bone and Joint Surgery (British Volume)"},{"key":"e_1_2_7_7_1","first-page":"2271","article-title":"Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991\u201394","volume":"33","author":"Dillon CF","year":"2006","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-109-1-18"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199903000-00013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2010.01.010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100080310"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(00)00191-3"},{"key":"e_1_2_7_13_1","unstructured":"WengertC BianchiG.Absolute orientation.Matlab File Exchange 2010. (Available from:http:\/\/www.mathworks.com\/matlabcentral\/fileexchange\/22422\u2010absoluteorientation accessed on August 2011)."},{"key":"e_1_2_7_14_1","unstructured":"BoydJL.The role of mechanical loading in osteoarthritis of the knee.DPhil Thesis University of Oxford Department of Engineering Science 2013."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4005171"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.1470171"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-011-0840-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10255840903389989"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.1385841"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.81B1.8928"},{"key":"e_1_2_7_21_1","unstructured":"AtkinsonP AtkinsonT HuangC DoaneR.A comparison of the mechanical and dimensional properties of the human medial and lateral patellofemoral ligaments[abstract].Proceedings of the 46th Orthopedic Research Society 2000."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(86)90019-9"},{"key":"e_1_2_7_23_1","first-page":"263","article-title":"Ligament length patterns, strength, and rotational axes of the knee joint","volume":"117","author":"Trent PS","year":"1976","journal-title":"Clinical Orthopaedics and Related Research"},{"issue":"3","key":"e_1_2_7_24_1","first-page":"358","article-title":"The mechanics of the knee and prosthesis design","volume":"60","author":"Goodfellow JW","year":"1978","journal-title":"Journal of Bone and Joint Surgery (British Volume)"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2007.03.004"}],"container-title":["International Journal for Numerical Methods in Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcnm.2740","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnm.2740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T02:02:00Z","timestamp":1696644120000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnm.2740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,2]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/cnm.2740"],"URL":"https:\/\/doi.org\/10.1002\/cnm.2740","archive":["Portico"],"relation":{},"ISSN":["2040-7939","2040-7947"],"issn-type":[{"value":"2040-7939","type":"print"},{"value":"2040-7947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,2]]},"article-number":"e02740"}}