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Recently, computational modeling combined with finite element method has been used to model AVP through the study of pelvic floor muscle and connective tissue impairments on the anterior vaginal wall (AVW). Also, the effects of pelvic organ displacements on the AVW were studied numerically. In our current work, an MRI\u2010based full\u2010scale biofidelic computational model of the female pelvic system composed of the urinary bladder, vaginal canal, and the uterus was developed, and a novel finite element method framework was employed to simulate vaginal tissue stiffening and also bladder filling due to expansion for the first time. A mesh convergence study was conducted to choose a computationally efficient mesh, and a non\u2010linear hyperelastic Yeoh's material model was adopted for the study. The AVW displacements, mechanical stresses, and strains were estimated at varying degrees of bladder fills and vaginal tissue stiffening. Both bladder filling and vaginal stiffening were found to increase the stress concentration on the AVW with varying trends, which have been discussed in detail in the paper. To our knowledge, this study is the first to estimate the individual and combined effects of bladder filling and vaginal tissue stiffening due to prolapse on the AVW. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cnm.2767","type":"journal-article","created":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T04:53:09Z","timestamp":1452055989000},"source":"Crossref","is-referenced-by-count":28,"title":["A biofidelic computational model of the female pelvic system to understand effect of bladder fill and progressive vaginal tissue stiffening due to prolapse on anterior vaginal wall"],"prefix":"10.1002","volume":"32","author":[{"given":"Arnab","family":"Chanda","sequence":"first","affiliation":[{"name":"Department of Aerospace Engineering and Mechanics University of Alabama  Tuscaloosa 35487 AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinu","family":"Unnikrishnan","sequence":"additional","affiliation":[{"name":"Department of Aerospace Engineering and Mechanics University of Alabama  Tuscaloosa 35487 AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly E.","family":"Richter","sequence":"additional","affiliation":[{"name":"Division of Urogynecology and Pelvic Reconstructive Surgery, Department of Obstetrics and Gynecology University of Alabama at Birmingham  1720 2nd Ave S Birmingham AL 35233 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Alabama at Birmingham  1720 2nd Ave S Birmingham AL 35233 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,2]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1111","article-title":"Pelvic organ prolapse","volume":"81","author":"Kuncharapu I","year":"2010","journal-title":"American Family Physician"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000175832.13266.bb"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4030967"},{"key":"e_1_2_6_5_1","volume-title":"Biomechanical Analyses of Anterior Vaginal Wall Prolapse: MR Imaging and Computer Modeling Studies","author":"Chen L","year":"2008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-05445-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000227786.69257.a8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-012-1801-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-010-1161-x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.08.036"},{"key":"e_1_2_6_11_1","unstructured":"YamadaH EvansFG.Strength of biological materials.Williams&Wilkins 1970;297."},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1097\/00006250-198812000-00028","article-title":"A. technique to study the passive supports of the uterus","volume":"72","author":"Bartscht KD","year":"1988","journal-title":"Obstetrics and Gynecology"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-011-1586-x"},{"key":"e_1_2_6_14_1","unstructured":"LuoJ.Biomechanical analyses of posterior vaginal prolapse: MR imaging and computer modeling studies. 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