{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:59:43Z","timestamp":1781657983854,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL109597"],"award-info":[{"award-number":["R01HL109597"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Numer Methods Biomed Eng"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mitral regurgitation (MR) is a result of mitral valve (MV) pathology. Its etiology can be categorized as degenerative or functional MR. Ring annuloplasty aims to reconfigure a dilated mitral annulus to its normal size and shape. We investigated the effect of annuloplasty ring shape on MR outcome using our established 3\u2010dimensional (3\u2010D) echocardiography\u2010based computational MV evaluation protocols. Virtual patient MV models were created from 3\u2010D transesophageal echocardiographic data in patients with MR because of mitral annular dilation. Two distinct annuloplasty rings (Physio II and GeoForm) were designed and virtually implanted to the patient MVs. Dynamic finite element simulations of MV function were performed for each MV after virtual ring annuloplasty of either ring, and physiologic and biomechanical characteristics of MV function were compared. Excessive stress values appeared primarily in the midanterior and midposterior regions, and lack of leaflet coaptation was found in pre\u2010annuloplasty patient MVs. Both rings demonstrated marked reduction of stresses and efficient leaflet coaptation. The Physio II ring demonstrated more evenly distributed stress reduction across the leaflets and annulus compared with the GeoForm ring. Conversely, the highly nonplanar curvature of the GeoForm ring more effectively increased leaflet coaptation compared with the Physio II ring. This indicates that the shape of annuloplasty ring affects post\u2010annuloplasty physiologic and biomechanical conditions, which can lead to tissue alteration over a longer period after ring annuloplasty. This virtual ring annuloplasty simulation strategy provides detailed physiologic and biomechanical information and may help better plan the optimal ring selection and improved patient\u2010specific MV repairs.<\/jats:p>","DOI":"10.1002\/cnm.2831","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T21:36:42Z","timestamp":1473284202000},"source":"Crossref","is-referenced-by-count":9,"title":["Computational virtual evaluation of the effect of annuloplasty ring shape"],"prefix":"10.1002","volume":"33","author":[{"given":"Ahnryul","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Internal Medicine The University of Texas Health Science Center at Houston  Houston TX USA"},{"name":"Department of Bio\u2010Mechatronic Engineering Sungkyunkwan University  Suwon Gyeonggi Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"McPherson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Internal Medicine The University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunggun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Internal Medicine The University of Texas Health Science Center at Houston  Houston TX USA"},{"name":"Department of Bio\u2010Mechatronic Engineering Sungkyunkwan University  Suwon Gyeonggi Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,5]]},"reference":[{"issue":"3","key":"e_1_2_7_2_1","first-page":"36","article-title":"Mitral regurgitation","volume":"140","author":"Pedrazzini GB","year":"2010","journal-title":"Swiss Med 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