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The parenchyma is described as an elastic homogenized media. It is irrigated by a space\u2010filling dyadic resistive pipe network, which represents the tracheobronchial tree. In this model, the tree and the parenchyma are strongly coupled. The tree induces an extra viscous term in the system constitutive relation, which leads, in the finite element framework, to a full matrix. We consider an efficient algorithm that takes advantage of the tree structure to enable a fast matrix\u2010vector product computation. This framework can be used to model both free and mechanically induced respiration, in health and disease. Patient\u2010specific lung geometries acquired from computed tomography scans are considered. Realistic Dirichlet boundary conditions can be deduced from surface registration on computed tomography images. The model is compared to a more classical exit compartment approach. Results illustrate the coupling between the tree and the parenchyma, at global and regional levels, and how conditions for the purely 0D model can be inferred. Different types of boundary conditions are tested, including a nonlinear Robin model of the surrounding lung structures.<\/jats:p>","DOI":"10.1002\/cnm.2873","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T09:22:39Z","timestamp":1487755359000},"source":"Crossref","is-referenced-by-count":27,"title":["A tree\u2010parenchyma coupled model for lung ventilation simulation"],"prefix":"10.1002","volume":"33","author":[{"given":"Nicolas","family":"Pozin","sequence":"first","affiliation":[{"name":"INRIA Paris  2 Rue Simone IFF 75012 Paris France"},{"name":"Sorbonne Universit\u00e9s, UPMC Univ. 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