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The present work aimed to determine the feasibility of using a method based on coronary computed tomography angiography (CCTA) and reduced\u2010order models (0D\u20101D) for the evaluation of coronary stenoses. The reduced\u2010order methodology (cFFR<jats:sub>RO<\/jats:sub>) was kept as simple as possible and did not include pressure drop or stenosis models. The geometry definition was incorporated into the physical model used to solve coronary flow and pressure. cFFRRO was assessed on a virtual cohort of 30 coronary artery stenoses in 25 vessels and compared with a standard approach based on 3D\u00a0computational fluid dynamics (cFFR<jats:sub>3D<\/jats:sub>). In this proof\u2010of\u2010concept study, we sought to investigate the influence of geometry and boundary conditions on the agreement between both methods. Performance on a per\u2010vessel level showed a good correlation between both methods (Pearson's product\u2010moment <jats:italic>R<\/jats:italic>=0.885, <jats:italic>P<\/jats:italic>&lt;0.01), when using cFFR<jats:sub>3D<\/jats:sub>\u00a0as the reference standard. The 95% limits of agreement were \u22120.116 and 0.08, and the mean bias was \u22120.018 (SD =0.05). Our results suggest no appreciable difference between cFFR<jats:sub>RO<\/jats:sub>\u00a0and cFFR<jats:sub>3D<\/jats:sub> with respect to lesion length and\/or aspect ratio. At a fixed aspect ratio, however, stenosis severity and shape appeared to be the most critical factors accounting for differences in both methods. Despite the assumptions inherent to the 1D\u00a0formulation, asymmetry did not seem to affect the agreement. The choice of boundary conditions is critical in obtaining a functionally significant drop in pressure. Our initial data suggest that this approach may be part of a broader risk assessment strategy aimed at increasing the diagnostic yield of cardiac catheterisation for in\u2010hospital evaluation of haemodynamically significant stenoses.<\/jats:p>","DOI":"10.1002\/cnm.2908","type":"journal-article","created":{"date-parts":[[2017,6,10]],"date-time":"2017-06-10T01:51:46Z","timestamp":1497059506000},"source":"Crossref","is-referenced-by-count":66,"title":["Estimating the accuracy of a reduced\u2010order model for the calculation of fractional flow reserve (FFR)"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9355-0973","authenticated-orcid":false,"given":"Etienne","family":"Boileau","sequence":"first","affiliation":[{"name":"Zienkiewicz Centre for Computational Engineering, Engineering Central, College of Engineering Swansea University Bay Campus  Swansea SA1 8EN UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Pant","sequence":"additional","affiliation":[{"name":"Zienkiewicz Centre for Computational Engineering, Engineering Central, College of Engineering Swansea University Bay Campus  Swansea SA1 8EN UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Roobottom","sequence":"additional","affiliation":[{"name":"Derriford Hospital and Peninsula Medical School, Plymouth Hospitals NHS Trust Derriford Rd, Crownhill, Plymouth  PL6 8DH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Sazonov","sequence":"additional","affiliation":[{"name":"Zienkiewicz Centre for Computational Engineering, Engineering Central, College of Engineering Swansea University Bay Campus  Swansea SA1 8EN UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Computer Science Swansea University  Swansea SA2 8PP UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghua","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Computer Science Swansea University  Swansea SA2 8PP UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perumal","family":"Nithiarasu","sequence":"additional","affiliation":[{"name":"Zienkiewicz Centre for Computational Engineering, Engineering Central, College of Engineering Swansea University Bay Campus  Swansea SA1 8EN UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199606273342604"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25222"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu278"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.01.087"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807611"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.096"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.04.012"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.925396"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205361"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22273"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.08.024"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.80.6.539"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.587196"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.04.008"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.066"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/2012.jama.11274"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.043"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY14M07_01"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.03.004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153070"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-017-0330-2"},{"key":"e_1_2_7_24_1","unstructured":"BessemsD.On the propagation of pressure and flow waves through the patient\u2010specific arterial system.Ph.D. Thesis: TU Eindhoven The Netherlands;2007."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.07.064"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-3-319-15799-3_11","volume-title":"Computational and Experimental Biomedical Sciences: Methods and Applications, LN Comput. 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