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In this paper, to reveal the influence of bronchial diameter on the airflow dynamics of pressure\u2010controlled mechanically ventilated patients, a new respiratory system model is presented that combines multigeneration airways with lungs. Furthermore, experiments and simulation studies to verify the model are performed. Finally, through the simulation study, it can be determined that in airway generations 2 to 7, when the diameter is reduced to half of the original value, the maximum air pressure (maximum air pressure in lungs) decreases by nearly 16%, the maximum flow decreases by nearly 30%, and the total airway pressure loss (sum of each generation pressure drop) is more than 5 times the original value. Moreover, in airway generations 8 to 16, with increasing diameter, the maximum air pressure, maximum flow, and total airway pressure loss remain almost constant. When the diameter is reduced to half of the original value, the maximum air pressure decreases by 3%, the maximum flow decreases by nearly 5%, and the total airway pressure loss increases by 200%. The study creates a foundation for improvement in respiratory disease diagnosis and treatment.<\/jats:p>","DOI":"10.1002\/cnm.2929","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T12:42:47Z","timestamp":1505392967000},"source":"Crossref","is-referenced-by-count":28,"title":["Influence of bronchial diameter change on the airflow dynamics based on a pressure\u2010controlled ventilation system"],"prefix":"10.1002","volume":"34","author":[{"given":"Shuai","family":"Ren","sequence":"first","affiliation":[{"name":"School of Automation Science and Electrical Engineering Beihang University  Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maolin","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Automation Science and Electrical Engineering Beihang University  Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6954-0537","authenticated-orcid":false,"given":"Yan","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Automation Science and Electrical Engineering Beihang University  Beijing 100191 China"},{"name":"Beijing Engineering Research Center of Diagnosis and Treatment of Respiratory and Critical Care Medicine Beijing Chaoyang Hospital  Beijing 100043 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Automation Science and Electrical Engineering Beihang University  Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua Douglas","family":"Zhang","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences University of Macau  Taipa 999078 Macau"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"The Biomedical Engineering Handbook, vol. 1, 2nd ed.CRC Press","author":"Behbehani K","year":"2000"},{"issue":"3","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/bja\/79.3.306","article-title":"Comparison of volume controlled with pressure controlled ventilation during one\u2010lung anaesthesia","volume":"79","author":"Tu\u02c7grul M","year":"1997","journal-title":"Br J Anaesth"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12206-015-0101-6"},{"issue":"6","key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.suc.2012.08.003","article-title":"Mechanical ventilation","volume":"92","author":"James MM","year":"2012","journal-title":"Surg Clin North Am"},{"issue":"4","key":"e_1_2_8_6_1","first-page":"292","article-title":"Pressure versus volume controlled modes in invasive mechanical ventilation","volume":"37","author":"Garnero AJ","year":"2013","journal-title":"Med Int"},{"issue":"2014","key":"e_1_2_8_7_1","first-page":"761712","article-title":"Pressure dynamic characteristics of pressure controlled ventilation system of a lung simulator","volume":"3","author":"Shi Y","year":"2014","journal-title":"Comput Math Methods Med"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.98.6.1445"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen067"},{"key":"e_1_2_8_10_1","volume-title":"Anesthesia Equipment","author":"Fang Z","year":"2000"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2013.07.003"},{"key":"e_1_2_8_12_1","unstructured":"TomalakW.Wybrane aspekty badania mechaniki oddychania i modelowania systemu oddechowego przy u\u02d9zyciu techniki oscylacji wymuszonych [Sc.D. 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