{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T14:58:38Z","timestamp":1780930718855,"version":"3.54.1"},"reference-count":75,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,30]],"date-time":"2019-03-30T00:00:00Z","timestamp":1553904000000},"content-version":"am","delay-in-days":311,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["1R21NS099896\u201001A1"],"award-info":[{"award-number":["1R21NS099896\u201001A1"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CBET\u20101301198"],"award-info":[{"award-number":["CBET\u20101301198"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CBET\u20101706921"],"award-info":[{"award-number":["CBET\u20101706921"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Numer Methods Biomed Eng"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Detailed hemodynamic analysis of blood flow in pathological segments close to aneurysm and stenosis has provided physicians with invaluable information about the local flow patterns leading to vascular disease. However, these diseases have both local and global effects on the circulation of the blood within the cerebral tree. The aim of this paper is to demonstrate the importance of extending subject\u2010specific hemodynamic simulations to the entire cerebral arterial tree with hundreds of bifurcations and vessels, as well as evaluate hemodynamic risk factors and waveform shape characteristics throughout the cerebral arterial trees. Angioarchitecture and in vivo blood flow measurement were acquired from healthy subjects and in cases with symptomatic intracranial aneurysm and stenosis. A global map of cerebral arterial blood flow distribution revealed regions of low to high hemodynamic risk that may significantly contribute to the development of intracranial aneurysms or atherosclerosis. Comparison of pre\u2010intervention and post\u2010intervention of pathological cases further shows large angular phase shift (~33.8\u00b0), and an augmentation of the peak\u2010diastolic velocity. Hemodynamic indexes of waveform analysis revealed on average a 16.35% reduction in the pulsatility index after treatment from lesion site to downstream distal vessels. The lesion regions not only affect blood flow streamlines of the proximal sites but also generate pulse wave shift and disturbed flow in downstream vessels. This <jats:italic>network effect<\/jats:italic> necessitates the use of large\u2010scale simulation to visualize both local and global effects of pathological lesions.<\/jats:p>","DOI":"10.1002\/cnm.2987","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T13:44:14Z","timestamp":1522417454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Quantification of near\u2010wall hemodynamic risk factors in large\u2010scale cerebral arterial trees"],"prefix":"10.1002","volume":"34","author":[{"given":"Mahsa","family":"Ghaffari","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of Illinois at Chicago  851 S Morgan St Chicago IL 60607 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Alaraj","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Illinois at Chicago  851 S Morgan St Chicago IL 60607 USA"},{"name":"Department of Neurosurgery University of Illinois at Chicago  912 South Wood Street Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjian","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Illinois at Chicago  912 South Wood Street Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong Joe","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Illinois at Chicago  851 S Morgan St Chicago IL 60607 USA"},{"name":"Department of Neurosurgery University of Illinois at Chicago  912 South Wood Street Chicago IL 60612 USA"},{"name":"Department of Radiology University of Illinois at Chicago  1740 W Taylor St Chicago IL 60612 USA"},{"name":"Center for MR Research University of Illinois at Chicago  1801 West Taylor Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fady T.","family":"Charbel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Illinois at Chicago  912 South Wood Street Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2694-630X","authenticated-orcid":false,"given":"Andreas A.","family":"Linninger","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Illinois at Chicago  851 S Morgan St Chicago IL 60607 USA"},{"name":"Department of Neurosurgery University of Illinois at Chicago  912 South Wood Street Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.1373"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4032056"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-014-1070-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-014-1119-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.5.3.293"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.01.018"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-012-0695-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(03)00088-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(98)00264-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.7.JNS111991"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2005.0044"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.10.028"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt044"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-10-84"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2701"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2016.09.031"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrnm.2011.09.001"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2006.07.008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2003.09.032"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10243"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10025"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.1427042"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(97)00125-5"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2008.05010.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-010-0132-1"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4941315"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007910050030"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10665-009-9281-3"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4031457"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-009-0449-9"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2622"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2014.08.005"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2014.2364522"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-014-0574-8"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3065"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000185686.28035.d2"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4528"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2015.02.001"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3624"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26087"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2017.01.012"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63578-5.50101-8"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2017.10.028"},{"issue":"2","key":"e_1_2_8_45_1","first-page":"126","article-title":"Medical image processing for fully integrated subject specific whole brain mesh generation","volume":"3","author":"Hsu C\u2010Y","year":"2015","journal-title":"Dent Tech"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-008-0420-1"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-012-0579-3"},{"key":"e_1_2_8_48_1","unstructured":"AntigaL Ene\u2010iordacheB RemuzziA.Centerline computation and geometric analysis of branching tubular surfaces with application to blood vessel modeling. In: In Proceedings of the 11thInternational Conference in Central Europe on Computer Graphics Visualization and Computer Vision Plzen Czech Republic;2003:11\u201318."},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-017-1617-y"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2009.03.030"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.2795948"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00897.2003"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bioeng.1.1.299"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1397"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.481234"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4001311"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.21.2035"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/25\/6\/014"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1114\/1.1537694"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-010-0102-7"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.3127252"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/1591019916668842"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2005.844159"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/31\/3\/002"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000168052.00426.65"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr253"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01087.2006"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2594"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cma.2005.04.014"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-006-9240-3"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.276.1.H257"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/fld.1786"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-016-0853-7"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12156"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-013-0828-0"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2014.09.034"}],"container-title":["International Journal for Numerical Methods in Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcnm.2987","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnm.2987","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnm.2987","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/cnm.2987","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnm.2987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T21:01:34Z","timestamp":1694984494000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnm.2987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,23]]},"references-count":75,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1002\/cnm.2987"],"URL":"https:\/\/doi.org\/10.1002\/cnm.2987","archive":["Portico"],"relation":{},"ISSN":["2040-7939","2040-7947"],"issn-type":[{"value":"2040-7939","type":"print"},{"value":"2040-7947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,23]]},"assertion":[{"value":"2017-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2987"}}