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While passing, a larger stone can get stuck and cause severe damage to ureter wall. Also, stones in the ureter obstructing the urine flow can cause pain and backflow of urine which in turn might require surgical intervention. The current study develops a 2D axisymmetric numerical model to gain an understanding of the ureter obstruction and its effects on the flow, which are critical in assessing the different treatment options. Transient computational analysis involving a two\u2010way fully coupled fluid\u2010structure interaction with the arbitrary Lagrangian\u2010Eulerian method between the ureteral wall and urine flow is conducted with an obstruction in the ureter. The ureter wall is modeled as an anisotropic hyperelastic material, data of which, is based on biaxial tests on human ureter from previous literature, while the incompressible Navier\u2010Stokes equations are solved to calculate urine flow. A finite element\u2013based monolithic solver is used for the simulations here. The obstruction is placed in the fluid domain as a circular stone at the proximal part of the ureter. One of the objectives of this study is to quantify the effect of the ureteral obstruction. A sharp jump in pressure gradient and wall shear stress, as well as retrograde urine flow, is observed as a result of the obstruction.<\/jats:p>","DOI":"10.1002\/cnm.3104","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T12:04:54Z","timestamp":1525781094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A fluid\u2010structure interaction (FSI)\u2010based numerical investigation of peristalsis in an obstructed human ureter"],"prefix":"10.1002","volume":"34","author":[{"given":"Ahmed Tasnub","family":"Takaddus","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering The University of Akron  Akron Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashanta","family":"Gautam","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering The University of Akron  Akron Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1008-5370","authenticated-orcid":false,"given":"Abhilash J.","family":"Chandy","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Indian Institute of Technology Bombay  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12018-011-9104-8"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.7762\/cnr.2015.4.3.137"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.5455\/msm.2014.26.297-302"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64173-9"},{"key":"e_1_2_5_6_1","series-title":"chap. 23","volume-title":"Human Anatomy","author":"Marieb E","year":"2007"},{"issue":"1","key":"e_1_2_5_7_1","first-page":"1","article-title":"An overview of treatment options for urinary stones","volume":"7","author":"Shafi H","year":"2016","journal-title":"Caspian J Internal Med"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05749.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2010.0208"},{"key":"e_1_2_5_10_1","series-title":"chap. 7","first-page":"45","volume-title":"Anatrophic Nephrolithomy","author":"Graham SD","year":"2009"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aju.2012.05.002"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4852-6"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1973.225.4.830"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.1998.12.45"},{"issue":"5710798","key":"e_1_2_5_15_1","first-page":"7","article-title":"Fluid structural analysis of urine flow in a stented ureter","volume":"2016","author":"G\u00f3mez\u2010Blanco J","year":"2016","journal-title":"Comput Math Methods Med"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022112067001156"},{"key":"e_1_2_5_17_1","unstructured":"Jimenez\u00a0LozanoJN.Peristaltic flow with application to ureteral biomechanics.Ph.D. Thesis: University Of Notre dame;2009."},{"key":"e_1_2_5_18_1","unstructured":"NajafiZ.Development of new treatment modalities for kidney\/ureter stones.Ph.D. Thesis: The University of Akron;2015."},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4034307"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022112070002653"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/32\/7\/002"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.3168367"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2011.12.019"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1971.221.5.1484"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655999750016203"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2011.581237"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1979.237.5.H620"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2012.761692"},{"issue":"3","key":"e_1_2_5_29_1","first-page":"1678","article-title":"Biaxial mechanical properties of human ureter under tension","volume":"11","author":"Rassoli A","year":"2014","journal-title":"Urol J"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2009.2025658"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2016.11.067"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0954411917750192"},{"key":"e_1_2_5_33_1","unstructured":"HosseiniG WilliamsJJ AvitalEJ MunjizaA XuD GreenJA.Computational simulation of urinary system. 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