{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:11:40Z","timestamp":1760346700210,"version":"3.41.2"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T00:00:00Z","timestamp":1532304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102017\u201004588"],"award-info":[{"award-number":["RGPIN\u20102017\u201004588"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Numer Methods Biomed Eng"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aortic valve is normally composed of 3 cusps. In one common lesion, 2 cusps are fused together. The conjoined area of the fused cusps is termed raphe. Occurring in 1% to 2% of the population, the bicuspid aortic valve (BAV) is the most common congenital cardiac malformation. The majority of BAV patients eventually require surgery. There is a lack in the literature regarding modeling of the raphe (geometry and material properties), its role and its influence on BAV function. The present study aims to propose improvements on these aspects. Three patient\u2010specific finite element models of BAVs were created based on 3D trans\u2010esophageal echocardiography measurements, and assuming age\u2010dependent material properties. The raphe was initially given the same material properties as its underlying cusps. Two levels of validation were performed; one based on the anatomical validation of the pressurized geometry in diastole (involving 7 anatomical measures), as simulated starting from the unpressurized geometry, and the other based on a functional assessment using clinical measurements in both systole and diastole (involving 16 functional measures). The pathology was successfully reproduced in the FE models of all 3 patients. To further investigate the role of the raphe, 2 additional scenarios were considered; (1) the raphe was considered as almost rigid, (2) the raphe was totally removed. The results confirmed the interpretation of the raphe as added stiffness in the fused cusp's rotation with respect to the aortic wall, as well as added support for stress distribution from the fused cusps to the aortic wall.<\/jats:p>","DOI":"10.1002\/cnm.3117","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T03:56:46Z","timestamp":1529035006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Investigation of raphe function in the bicuspid aortic valve and its influence on clinical criteria\u2014<scp>A<\/scp> patient\u2010specific finite element study"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6154-6045","authenticated-orcid":false,"given":"J\u00e9r\u00e9my","family":"Dallard","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering University of Ottawa  Ottawa Ontario 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