{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T13:11:00Z","timestamp":1773666660167,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002261","name":"\u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0438\u0439 \u0424\u043e\u043d\u0434 \u0424\u0443\u043d\u0434\u0430\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u044b\u0445 \u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439","doi-asserted-by":"publisher","award":["18\u201031\u201000065"],"award-info":[{"award-number":["18\u201031\u201000065"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Numer Methods Biomed Eng"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A new mathematical model of the cardiovascular system is proposed. The left ventricle is described by an axisymmetric multiscale model where myocardium is treated as an incompressible transversely isotropic medium with a realistic distribution of fibre orientation. Active tension and its regulation by Ca<jats:sup>2+<\/jats:sup> ions are described by our recent kinetic model. A lumped parameter model is used for the simulation of blood circulation, in which the left and right atria and the right ventricle are described by a system of ordinary differential equations for active pressure\u2010volume relationships. The stress and strain of the left ventricle myocardium were calculated by the finite element method implemented by the authors. The changes in the haemodynamics upon changes in preload of a healthy heart, upon physical exercise, and in case of atrioventricular block with different types of arrhythmias were simulated. To simulate the effect of stenosis or regurgitation of the aortic or mitral valves, the hydraulic and inertial flow resistances of the heart valves were set as functions of their orifice areas. The model reproduced a number of phenomena observed in clinical practice, including the classification of the severity of valve disease.<\/jats:p>","DOI":"10.1002\/cnm.3216","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T17:28:09Z","timestamp":1557768489000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Multiscale simulation of the effects of atrioventricular block and valve diseases on heart performance"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3871-2236","authenticated-orcid":false,"given":"Fyodor A.","family":"Syomin","sequence":"first","affiliation":[{"name":"Department of Biomechanics, Institute of Mechanics M.V. Lomonosov Moscow State University  1 Mitchurinsky Prosp. Moscow 119192 Russian Federation"},{"name":"Peoples' Friendship University of Russia (RUDN University)  6 Miklukho\u2010Maklaya St Moscow 117198 Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria V.","family":"Zberia","sequence":"additional","affiliation":[{"name":"Department of Biomechanics, Institute of Mechanics M.V. Lomonosov Moscow State University  1 Mitchurinsky Prosp. Moscow 119192 Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0447-7725","authenticated-orcid":false,"given":"Andrey K.","family":"Tsaturyan","sequence":"additional","affiliation":[{"name":"Department of Biomechanics, Institute of Mechanics M.V. Lomonosov Moscow State University  1 Mitchurinsky Prosp. Moscow 119192 Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0104-y"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2015.0083"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-017-9779-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcp.2012.09.015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2011.00043"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.107.119487"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.105.069534"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2008.04.012"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-017-0585-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00444.2004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-009-9774-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-12-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065146"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbs.2016.05.007"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13239-017-0327-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2931"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2017.02.021"},{"issue":"5","key":"e_1_2_6_19_1","first-page":"327","article-title":"Mechanical model of the left ventricle of the heart approximated by axisymmetric geometry","volume":"32","author":"Syomin FA","year":"2017","journal-title":"Russ J Num Analysis Math Model"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0006350912050181"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0006350914050224"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-12-54"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.103.033571"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(94)80652-6"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1341.026"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001667"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2005.12.014"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.12186"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00517-2"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00444.2002"},{"key":"e_1_2_6_31_1","unstructured":"Right heart catheterization \u2013 PCIpedia.http:\/\/www.pcipedia.org\/wiki\/Right_heart_catheterization. Accessed April 10 2019"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02441348"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP271788"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2005.06.016"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.1466"},{"key":"e_1_2_6_36_1","volume-title":"Handbook of local resistance and of friction","author":"Idel'chik IE","year":"1996"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2342-9-2"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.1.167"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.11.029"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx324"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep007"},{"key":"e_1_2_6_42_1","doi-asserted-by":"crossref","unstructured":"ProkseljK.Echocardiography of the mitral valve. In: Proceedings from the International Symposium MITRAL VALVE DISEASES IN CHILDREN AND ADULTS Sarajevo September 29 2016. Academy of Sciences and Arts of Bosnia and Herzegovina;2017;26\u201341.https:\/\/doi.org\/10.5644\/PI2017.168.03.","DOI":"10.5644\/PI2017.168.03"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00335-3"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.5.1743"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-016-0753-6"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2014.03.013"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.12.009"},{"key":"e_1_2_6_48_1","first-page":"793","article-title":"Assessment of mitral regurgitation by 3\u2010dimensional proximal flow convergence using magnetic resonance imaging: comparison with echo\u2010Doppler","volume":"34","author":"Gorodisky L","year":"2018","journal-title":"Int J Cardiovasc Imaging"}],"container-title":["International Journal for Numerical Methods in Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcnm.3216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnm.3216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnm.3216","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnm.3216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T02:13:12Z","timestamp":1693707192000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnm.3216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,6]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/cnm.3216"],"URL":"https:\/\/doi.org\/10.1002\/cnm.3216","archive":["Portico"],"relation":{},"ISSN":["2040-7939","2040-7947"],"issn-type":[{"value":"2040-7939","type":"print"},{"value":"2040-7947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,6]]},"assertion":[{"value":"2018-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3216"}}