{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:04:46Z","timestamp":1787065486266,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/I019472\/1; EP\/I020101\/1; EP\/K036939\/1"],"award-info":[{"award-number":["EP\/I019472\/1; EP\/I020101\/1; EP\/K036939\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Numer Methods Biomed Eng"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Identification and characterization of nodules in soft tissue, including their size, shape, and location, provide a basis for tumor identification. This study proposes an inverse finite\u2010element (FE) based computational framework, for characterizing the size of examined tissue sample and detecting the presence of embedded tumor nodules using instrumented palpation, without a priori anatomical knowledge. The inverse analysis was applied to a model system, the human prostate, and was based on the reaction forces which can be obtained by trans\u2010rectal mechanical probing and those from an equivalent FE model, which was optimized iteratively, by minimizing an error function between the two cases, toward the target solution. The tumor nodule can be identified through its influence on the stress state of the prostate. The effectiveness of the proposed method was further verified using a realistic prostate model reconstructed from magnetic resonance (MR) images. The results show the proposed framework to be capable of characterizing the key geometrical indices of the prostate and identifying the presence of cancerous nodules. Therefore, it has potential, when combined with instrumented palpation, for primary diagnosis of prostate cancer, and, potentially, solid tumors in other types of soft tissue.<\/jats:p>","DOI":"10.1002\/cnm.3369","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T02:39:18Z","timestamp":1590460758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Identification of tumor nodule in soft tissue: An inverse finite\u2010element framework based on mechanical characterization"],"prefix":"10.1002","volume":"36","author":[{"given":"Antonio","family":"Candito","sequence":"first","affiliation":[{"name":"Institute of Mechanical, Process and Energy Engineering, School of Engineering and Physical Sciences Heriot\u2010Watt University  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Palacio\u2010Torralba","sequence":"additional","affiliation":[{"name":"Institute of Mechanical, Process and Energy Engineering, School of Engineering and Physical Sciences Heriot\u2010Watt University  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Jim\u00e9nez\u2010Aguilar","sequence":"additional","affiliation":[{"name":"Servicio de Oncolog\u00eda M\u00e9dica Hospital 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Good","sequence":"additional","affiliation":[{"name":"Edinburgh Urological Cancer Group, Division of Pathology Laboratories, Institute of Genetics and Molecular Medicine Western General Hospital, The University of Edinburgh  Edinburgh UK"},{"name":"Department of Urology, NHS Lothian Western General Hospital  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"McNeill","sequence":"additional","affiliation":[{"name":"Edinburgh Urological Cancer Group, Division of Pathology Laboratories, Institute of Genetics and Molecular Medicine Western General Hospital, The University of Edinburgh  Edinburgh UK"},{"name":"Department of Urology, NHS Lothian Western General Hospital  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Reuben","sequence":"additional","affiliation":[{"name":"Institute of Mechanical, Process and Energy Engineering, School of Engineering and Physical Sciences Heriot\u2010Watt University  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2681-0362","authenticated-orcid":false,"given":"Yuhang","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Mechanical, Process and Energy Engineering, School of Engineering and Physical Sciences Heriot\u2010Watt University  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.05.004"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"33","article-title":"Global cancer statistics: 2011","volume":"49","author":"Jemal A","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0954411917734257"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2014.09.027"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/016173469802000403"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.03.017"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2013.05.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10665-014-9740-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4927572"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/52\/6\/002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.04.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcs.209"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-012-0984-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-012-0936-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-013-1118-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1557\/mrc.2018.98"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsolstr.2016.01.001"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcs.138"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2704"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2013.789100"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2010.10.013"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2004.03.004"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-2008-44-505"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12541-009-0079-z"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/nme.1620170504"},{"key":"e_1_2_7_27_1","unstructured":"ABAQUSv6.14 Documentation Benchmark Manual Section 2.3.5: Hourglass control for reduced\u2010integration elements."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1137\/0111030"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1109\/ICCV.2005.128"},{"key":"e_1_2_7_30_1","first-page":"1","article-title":"Methods for non\u2010linear least squares problems","volume":"2","author":"Madsen K","year":"2004","journal-title":"Inform Math Model"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2017.01.021"},{"issue":"1","key":"e_1_2_7_32_1","doi-asserted-by":"crossref","first-page":"e02734","DOI":"10.1002\/cnm.2734","article-title":"Patient specific modeling of palpation\u2010based prostate cancer diagnosis: effects of pelvic cavity anatomy and intrabladder pressure","volume":"32","author":"Palacio\u2010Torralba J","year":"2015","journal-title":"Int J Numer Method Biomed Eng"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.179077"}],"container-title":["International Journal for Numerical Methods in Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcnm.3369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnm.3369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnm.3369","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnm.3369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:53:09Z","timestamp":1693875189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnm.3369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,15]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/cnm.3369"],"URL":"https:\/\/doi.org\/10.1002\/cnm.3369","archive":["Portico"],"relation":{},"ISSN":["2040-7939","2040-7947"],"issn-type":[{"value":"2040-7939","type":"print"},{"value":"2040-7947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,15]]},"assertion":[{"value":"2018-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3369"}}