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GOA is the optimization algorithm, which is utilized for selecting the optimized tuning parameters of the PID controller also solves the nonlinear system parameter identification problem. The novelty of the proposed study is to stabilize the glucose level in blood for type 1 diabetic patients by infusion of insulin in reduced time with optimal quantity. Without any intervention to the normal activities of patients, the supply of insulin injection and glucose monitoring is performed automatically for type 1 diabetic patients using this controller. In between the measured variable and set point, the difference is calculated by the PID controller to evaluate an error values. In realistic patient oriented conditions, the control performance evaluation, control optimization, and advanced patient modelling should be highly concentrated during the research\/analysis on blood glucose control. Evaluation is performed to analyze control performances and implementation is done on Simulink\/MATLAB environment. The performance analysis of the type 1 diabetes mellitus system with GOA technique is also discussed and to improve the control performance, to optimize the controller parameters. The simulation results have proved the substantial improvement in the performance of proposed algorithm with the better results achieved than the other conventional controllers such as PSO\u2010PID and EHO\u2010PID.<\/jats:p>","DOI":"10.1002\/cnm.3371","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T13:56:45Z","timestamp":1590501405000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["An adaptive technique based blood glucose control in type\u20101 diabetes mellitus patients"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0170-7561","authenticated-orcid":false,"given":"Anchana P.","family":"Belmon","sequence":"first","affiliation":[{"name":"Department of ECE Maria College of Engineering &amp; Technology  Attoor India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeraldin","family":"Auxillia","sequence":"additional","affiliation":[{"name":"Department of ECE St. Xavier's Catholic College of Engineering  Chunkankadai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2012.09.003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2009.06.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","unstructured":"SoyluS DanismanK SacuIE AlciM. 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