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In order to assess the present status of the coronary artery stenosis severity, and thereby selecting the most appropriate type of treatment for each patient, fractional flow reserve (FFR), instantaneous wave free\u2010ratio (iFR), and coronary flow reserve (CFR) are calculated. To examine FFR, iFR, and CFR results, the effect of geometric features of stenoses, including diameter reduction (%), lesion length (LL), and minimum lumen diameter (MLD), is studied on them. It is observed that FFR is a more conservative index than iFR and CFR to assess the severity of coronary stenosis. In addition, it is seen that FFR, iFR, and CFR decrease by increasing LL and decreasing MLD. Therefore, the morphological indices, LL\/MLD and LL\/MLD\u03024, with the calculated conservative cut\u2010off values equal to 5.5 and 3.6, are considered. Next, some controversial clinical hypotheses about the assessment of the severity of coronary stenosis are evaluated numerically. These include the examination of FFR, iFR, and CFR accuracies, investigating the effect of coronary hyperemia on iFR, as well as the reliability of the hybrid iFR\u2010FFR decision\u2010making strategy. The presented numerical model can also be used as a predictive tool to identify the atherosuseptible sites of arteries by calculating the time\u2010averaged wall shear stress (TAWSS), oscillatory shear index (OSI), and relative residence time (RRT).<\/jats:p>","DOI":"10.1002\/cnm.3382","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T15:34:47Z","timestamp":1593876887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["High precision invasive <scp>FFR<\/scp>, <scp>low\u2010cost<\/scp> invasive <scp>iFR<\/scp>, or <scp>non\u2010invasive CFR<\/scp>?: optimum assessment of coronary artery stenosis based on the <scp>patient\u2010specific<\/scp> computational models"],"prefix":"10.1002","volume":"36","author":[{"given":"Farshad","family":"Tajeddini","sequence":"first","affiliation":[{"name":"Center of Excellence in Energy Conversion, School of Mechanical Engineering Sharif University of Technology  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9016-1830","authenticated-orcid":false,"given":"Mohammad Reza","family":"Nikmaneshi","sequence":"additional","affiliation":[{"name":"Center of Excellence in Energy Conversion, School of Mechanical Engineering Sharif University of Technology  Tehran Iran"},{"name":"Department of Radiation Oncology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4774-0896","authenticated-orcid":false,"given":"Bahar","family":"Firoozabadi","sequence":"additional","affiliation":[{"name":"Center of Excellence in Energy Conversion, School of Mechanical Engineering Sharif University of Technology  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein Ali","family":"Pakravan","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering Shiraz University  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Hossein","family":"Ahmadi Tafti","sequence":"additional","affiliation":[{"name":"Tehran Heart Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Afshin","sequence":"additional","affiliation":[{"name":"Center of Excellence in Energy Conversion, School of Mechanical Engineering Sharif University of Technology  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.191261"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000442015.53336.12"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2017.11.029"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2013.0866"},{"key":"e_1_2_7_6_1","unstructured":"RoustaeiM NikmaneshiMR FiroozabadiB.Investigation of Fluid\u2010Structure interaction effect on Low\u2010Density Lipoprotein (LDL) penetration into multilayer arterial wall. 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