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In this study, we coupled a lumped\u2010parameter model with a patient\u2010specific three\u2010dimensional (3D) model which included a modified Blalock\u2010Taussig (MBT) shunt. By forming a closed loop, we investigated the effects of certain parameters on the flow rates and the pressures at different locations of the developed network. A local sensitivity analysis on an initial zero\u2010dimensional (0D) closed\u2010loop model was conducted. The 0D lumped parameter (LP) model was then refined based on the results of the multiscale 0D\u20103D model and the local sensitivity analysis was repeated for the refined 0D model. It was shown that the maximum pressure of the pulmonary bed had the highest sensitivity of 94% to the diameter of MBT shunt. We observed that the existence of the flow in the shunt during the diastole caused an elevated wall shear stress (WSS) in the pulmonary artery. In this work, we calculated the flow velocity and pressure field in a 3D patient\u2010specific aorta with an MBT shunt, and then we used the results to increase the accuracy of our LP model to simulate numerous 0D simulations in a significantly shorter time, which is potentially applicable for medical decision\u2010making.<\/jats:p>","DOI":"10.1002\/cnm.3436","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T08:34:33Z","timestamp":1610699673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multiscale modeling of a modified\n                    <scp>Blalock\u2010Taussig<\/scp>\n                    surgery in a\n                    <scp>patient\u2010specific<\/scp>\n                    tetralogy of Fallot"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0156-9739","authenticated-orcid":false,"given":"Hamed","family":"Keramati","sequence":"first","affiliation":[{"name":"NUS Graduate School for Integrative Sciences and Engineering (NGS) National University of Singapore  Singapore Singapore"},{"name":"Department of Biomedical Engineering National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lex","family":"van Houts","sequence":"additional","affiliation":[{"name":"Cardiovascular Biomechanics Group, Department of Biomedical Engineering Eindhoven University of Technology  North Brabant Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching Kit","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Department of Paediatrics 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