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Current clinical practice, based on spirometry and cardiopulmonary exercise tests, does not consider local changes, providing an average at\u2010the\u2010mouth estimation of residual functionality. Computational Fluid Dynamics (CFD) has proved a valuable solution to obtain quantitative and local information about airways airflow dynamics. A CFD investigation was performed on the airway tree of a left\u2010upper pulmonary lobectomy patient, to quantify the effects of the postoperative alterations. The patient\u2010specific bronchial models were reconstructed from pre\u2010 and postoperative CT scans. A parametric laryngeal model was merged to the geometries to account for physiological\u2010like inlet conditions. Numerical simulations were performed in Fluent. The postoperative configuration revealed fluid dynamic variations in terms of global velocity (+23%), wall pressure (+48%), and wall shear stress (+39%). Local flow disturbances emerged at the resection site: a high\u2010velocity peak of 4.92\u2009m\/s was found at the left\u2010lower lobe entrance, with a local increase of pressure at the suture zone (18\u2009Pa). The magnitude of pressure and secondary flows increased in the trachea and flow dynamics variations were observed also in the contralateral lung, causing altered lobar ventilation. The results confirmed that CFD is a patient\u2010specific approach for a quantitative evaluation of fluid dynamics parameters and local ventilation providing additional information with respect to current clinical approaches.<\/jats:p>","DOI":"10.1002\/cnm.3462","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T10:46:44Z","timestamp":1617792404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Computational fluid dynamics of the airways after left\u2010upper pulmonary lobectomy: A case study"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8834-9706","authenticated-orcid":false,"given":"Marta","family":"Tullio","sequence":"first","affiliation":[{"name":"Dipartimento di Elettronica Informazione e Bioingegneria, Politecnico di Milano  Milan 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