{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:43:51Z","timestamp":1753868631857,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Numer Methods Biomed Eng"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A two\u2010chamber inflation\u2010deflation test was recently proposed as a diagnostic method to determine parameters of the intermittent pneumatic compression used as an effective therapeutic modality for lymphedematous limbs. It is crucial that the recorded trends for residual tissue deformations are understood in terms of specific properties of subcutaneous tissue and skin to support diagnostic process. This paper presents a mechanical model of lymphedematous legs in two\u2010chamber tests. The cylindrical geometry composed of layers of skin, modeled as hyperelastic medium, and subcutaneous tissue, modeled as fluid saturated hyperporoelastic medium, is assumed. The results of finite element simulations show the possibility of such combinations of the properties of skin (rigidity) and subcutaneous tissue (rigidity and permeability), which ensures that the model predictions resemble the evolution of tissue residual deformations observed in the two\u2010chamber test. The stiffness and permeability appeared to be the most crucial tissue property determining trend lines of residual deformations. The analysis of the components of displacement of solid matrix and pore fluid pressure explains the mechanisms that are responsible for particular tissue behavior. The moderate role of skin and limitations related to the mechanical and geometrical model assumptions are indicated. Recommendations for treating lymphedema using intermittent compression therapy in relation to the results of the two\u2010chamber test and properties of tissues are discussed.<\/jats:p>","DOI":"10.1002\/cnm.3537","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T07:42:39Z","timestamp":1633419759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Simulation\u2010based reasoning of residual tissue deformations in a two\u2010chamber test of a lymphedematous leg"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8253-2435","authenticated-orcid":false,"given":"Mariusz","family":"Kaczmarek","sequence":"first","affiliation":[{"name":"Kazimierz Wielki University  Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Nowak","sequence":"additional","affiliation":[{"name":"Kazimierz Wielki University  Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldemar L.","family":"Olszewski","sequence":"additional","affiliation":[{"name":"Medical Research Center Polish Academy of Sciences  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzanna","family":"Zaleska","sequence":"additional","affiliation":[{"name":"Medical Research Center Polish Academy of Sciences  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"volume-title":"Lymphoedema. 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