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The extraction of the optical properties from the reflectance spectrum using analytical solutions is laborious. Model\u2010based light tissue interaction studies help in quantifying the optical properties. This work presents the use of finite element models of light tissue interaction for this purpose. A bilayer model mimicking human skin was considered and the diffused reflectance spectra at multiple detector points were generated using finite element modelling for varying melanin concentration, epidermal thickness, blood volume fraction, oxygen saturation and scattering components. The reflectance value based on varying optical parameters from multiple detection points lead to the generation of a look\u2010up table (LUT), which is further used for finding the tissue parameters that contribute to the spatially resolved reflectance values. The tissue parameters estimated after inverse modelling showed a high degree of agreement with the expected tissue parameters for a test dataset different from the training dataset.<\/jats:p>","DOI":"10.1002\/cnm.3546","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T09:19:31Z","timestamp":1635671971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quantification of soft tissue parameters from spatially resolved diffuse reflectance finite element models"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5421-0925","authenticated-orcid":false,"given":"Vysakh","family":"Vasudevan","sequence":"first","affiliation":[{"name":"Biophotonics Laboratory, Department of Applied Mechanics Indian Institute of Technology Madras  Chennai 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