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A case study of a stenosed and symptomatic carotid bifurcation was considered to show the influence of the wall\u2010resilience assumption on the flow parameters obtained with numerical simulations. Patient\u2010specific data concerning the geometry and flow conditions were collected and used to carry out two\u2010way coupled fluid structure interaction simulations of the pulsatile blood flow through carotid artery. The wall compliance was considered separately as related to the wall\u2010elasticity and as associated with the reaction of the loose connective tissue surrounding the carotid bifurcation. The obtained hemodynamic parameters were compared to those which were found in rigid\u2010wall simulations. The difference between the results obtained for rigid\u2010wall and compliant\u2010wall approaches for the peak\u2010systolic area\u2010averaged wall shear stress achieved 35%, whereas the difference between the time\u2010averaged local vorticity and shear strain reached, respectively, 42% and 43%. The influence of the highly resilient wall on the monitored hemodynamic parameters was significant even if time\u2010averaged values are compared, which suggests that these metrics are considerably overestimated if the wall compliance is not considered. Moreover, the findings show that the mechanical response of the loose connective tissue cannot be neglected in blood flow simulations. Additionally, this study indicates that stiffening of the arterial wall due to atherosclerosis significantly rises hemodynamic parameters. This explains the therapeutic benefits of surgical removal of plaque lesions formed in the carotid bifurcation (endarterectomy).<\/jats:p>","DOI":"10.1002\/cnm.3630","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T09:26:32Z","timestamp":1653038792000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Fluid structure interaction versus rigid\u2010wall approach in the study of the symptomatic stenosed carotid artery: Importance of wall compliance and resilience of loose connective tissue"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0107-838X","authenticated-orcid":false,"given":"Daniel","family":"Jodko","sequence":"first","affiliation":[{"name":"Institute of Turbomachinery Lodz University of Technology  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Jeckowski","sequence":"additional","affiliation":[{"name":"Department of Experimental Surgery Medical University of Lodz  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9870-8370","authenticated-orcid":false,"given":"Zbigniew","family":"Tyfa","sequence":"additional","affiliation":[{"name":"Institute of Turbomachinery Lodz University of Technology  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5277\/ABB\u201000682\u20102016\u201003"},{"issue":"1","key":"e_1_2_9_3_1","first-page":"40","article-title":"Pathogenesis of atherosclerosis: A multifactorial process","volume":"7","author":"Singh RB","year":"2002","journal-title":"Exp Clin Cardiol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11936\u2010017\u20100564\u20100"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.029606"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.06.014"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.059"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00047.2009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010012\u20100695\u20100"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hjc.2016.11.019"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010bioeng\u2010092419\u2010060810"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12572-016-0161-6"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina54030042"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2014.02.039"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbe.2018.01.004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00171.2001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237\u2010013\u20100527\u20107"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2011.593762"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2595"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijengsci.2020.103341"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmecsci.2019.06.029"},{"key":"e_1_2_9_22_1","unstructured":"SousaLC CastroCF Ant\u00f3nioCC AzevedoE.Fluid\u2010structure interaction modeling of blood flow in a non\u2010Stenosed common carotid artery bifurcation. 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