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The finite element model of healthy human lumbosacral segment was modified to incorporate NPDS device insertion at L4\u2013L5 segment. Bioflex and DIAM were used as PSDS\u2010based and IPS\u2010based NPDS devices, respectively. As a comparison, lumbar interbody fusion with rigid stabilization was also simulated at L4\u2013L5. For static loading, segmental range of motion (ROM) of the models under moments of four physiological motions was computed using hybrid testing protocol. For vibration loading, resonant modes and dynamic stress of the models under vertical excitation were extracted through random response analysis. The results showed that compared with the rigid fusion model, ROM of the nonfusion models was higher at L4\u2013L5 level but lower at adjacent levels (L1\u2013 L2, L2\u2013L3, L3\u2013L4, L5\u2013S1). Compared with the Bioflex model, the DIAM model produced higher ROM at L4\u2013L5 level but lower ROM at adjacent levels, especially under lateral bending and axial rotation; resonant frequency of the DIAM model was slightly lower; dynamic response of nucleus stress at L4\u2013L5 level was slightly higher for the DIAM model, and the dynamic stress at adjacent levels was no obvious difference between the nonfusion models. This study reveals biomechanical differences between the Bioflex and DIAM systems, which may provide references for selecting surgical approaches in clinical practice.<\/jats:p>","DOI":"10.1002\/cnm.3645","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T05:25:50Z","timestamp":1661232350000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biomechanical analysis of lumbar nonfusion dynamic stabilization using a pedicle screw\u2010based dynamic stabilizer or an interspinous process spacer"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0392-188X","authenticated-orcid":false,"given":"Wei","family":"Fan","sequence":"first","affiliation":[{"name":"School of Mechanical Engineering and Automation Northeastern University  Shenyang 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