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These nonlinearities pose a significant challenge for numerical solvers, increasing the computational time by several orders of magnitude. Simplifying assumptions can reduce the computational time significantly, but this usually comes at the expense of simulation accuracy. This study proposed the use of reduced order modeling (ROM) techniques to capture experimentally measured displacement fields of rat vaginal tissue during inflation testing in order to attain both the accuracy of higher\u2010fidelity models and the speed of simpler simulations. The proper orthogonal decomposition (POD) method was used to extract the significant information from FE simulations generated by varying the luminal pressure and the parameters that introduce the anisotropy in the selected constitutive model. A new data\u2010driven (DD) variational multiscale (VMS) ROM framework was extended to obtain the displacement fields of rat vaginal tissue under pressure. For comparison purposes, we also investigated the classical Galerkin ROM (G\u2010ROM). In our numerical study, both the G\u2010ROM and the DD\u2010VMS\u2010ROM decreased the FE computational cost by orders of magnitude without a significant decrease in numerical accuracy. Furthermore, the DD\u2010VMS\u2010ROM improved the G\u2010ROM accuracy at a modest computational overhead. Our numerical investigation showed that ROM has the potential to provide efficient and accurate computational tools to describe vaginal deformations, with the ultimate goal of improving maternal health.<\/jats:p>","DOI":"10.1002\/cnm.3660","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T05:45:03Z","timestamp":1667627103000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>Data\u2010driven<\/scp> variational multiscale reduced order modeling of vaginal tissue inflation"],"prefix":"10.1002","volume":"39","author":[{"given":"William","family":"Snyder","sequence":"first","affiliation":[{"name":"STRETCH Lab, Department of Biomedical Engineering and Mechanics Virginia Tech  Blacksburg Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"McGuire","sequence":"additional","affiliation":[{"name":"STRETCH Lab, Department of Biomedical Engineering and Mechanics Virginia Tech  Blacksburg Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhong","family":"Mou","sequence":"additional","affiliation":[{"name":"Department of Mathematics Virginia Tech  Blacksburg Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Dillard","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Mechanics Virginia Tech  Blacksburg Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Traian","family":"Iliescu","sequence":"additional","affiliation":[{"name":"Department of Mathematics Virginia Tech  Blacksburg Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"De Vita","sequence":"additional","affiliation":[{"name":"STRETCH Lab, Department of Biomedical Engineering and Mechanics Virginia Tech  Blacksburg Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2021-005671"},{"issue":"2","key":"e_1_2_12_3_1","first-page":"1","article-title":"Births: final data for 2019","volume":"70","author":"Martin JA","year":"2021","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68704-7"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4049226"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2011.12.002"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2015.02.041"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2019.0022"},{"key":"e_1_2_12_9_1","volume-title":"Turbulence, Coherent Structures","author":"Holmes P","year":"1996"},{"key":"e_1_2_12_10_1","volume-title":"Proper Orthogonal Decomposition: Theory and Reduced\u2010Order Modelling. 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